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Water-soluble polymeric carriers for drug delivery

  • US 5,648,506 A
  • Filed: 06/05/1995
  • Issued: 07/15/1997
  • Est. Priority Date: 06/04/1992
  • Status: Expired due to Term
First Claim
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1. A taxol derivative having the general formula R1 --T--R2 :

  • wherein R1 =--X--P or --OH, and R1 is located on the 2'"'"'-carbon of the taxol side chain;

    wherein R1 =--X--P or --OH, and R2 is located on the 7-carbon atom of the ring structure;

    but R1 and R2 are not simultaneously --OH;

    and the drug taxol T, is covalently linked to a water-soluble polymer P, based on polyethylene glycol, through a covalent linking group X,wherein P is selected from a branched chain polyethylene glycol, a star polyethylene glycol or a branched copolymer of a linear polyethylene glycol and a functional monomer, andwherein X is selected from ester, diester, urethane, amide, secondary or tertiary amine or ether linking groups.

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