Metal reinforced polymer stent

• US 5,649,977 A
• Filed: 09/22/1994
• Issued: 07/22/1997
• Est. Priority Date: 09/22/1994
• Status: Expired due to Term

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Campbell, Patrick K.
• Primary Examiner(s): Weiss, John G.
• Assistant Examiner(s): SNOW, BRUCE EDWARD
• Application Number:
  US08/310,579
• Time in Patent Office: 1,034 Days
• Field of Search: 623/1, 623/11, 606/192, 606/194, 606/195, 606/198, 24/30.5 P, 24/16 PB
• US Class Current: 623/1.15
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/92 Stents in the form of a rolled-up sheet expanding after insertion into the vessel , e.g. with a spiral shape in cross-section
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device
• CPC Class Codes: Y10T 156/1002 with permanent bending or reshaping or surface deformation of self sustaining lamina
• CPC Class Codes: Y10T 156/1038 Hollow cylinder article
• CPC Class Codes: Y10T 156/1056 Perforating lamina
• CPC Class Codes: Y10T 156/108 Flash, trim or excess removal

Abstract

The metal reinforced polymer stent for use in blood vessels is formed of a thin planar sheet of metal, and is laminated on at least one side with a thin film of a polymer capable of absorbing and releasing therapeutic drugs. The thin planar sheet of metal is formed as a sheet and cut in a shape that can be used as a stent, the ends of which can be joined in a contractible, expandable loop.

Claims

1. A stent for use in maintaining the patency of blood vessels, the stent comprising:

a metal reinforcement member having first and second side surfaces, said reinforcement member having first and second ends and a main body portion between the first and second ends, said reinforcement member being capable of being rolled up into a cylindrical configuration whereby the first end overlaps the second end, said first end of the reinforcement member comprising a surface extending in a plane end defining a slot for receiving the second end, the second end and the main body portion being insertable through said slot so as to form a loop, said slot in the first end having a plurality of teeth for releasably engaging the second end and the main body portion, said plurality of teeth extending from said slot at an angle of about 45°

out of the plane of the first end of the reinforcement member, and the second end and the main body portion having a corresponding plurality of apertures for receiving said plurality of teeth to adjustably retain the second end and the main body portion in said slot, whereby when said reinforcement member is in said cylindrical configuration, said slot and said means for releasably engaging said slot permit radial expansion of said reinforcement member and resist radial compression of said reinforcement member; and

at least one layer of a polymer bonded to at least one of the side surfaces of the reinforcement member, said polymer being capable of absorbing and releasing therapeutic drugs.

2. The stent of claim 1, wherein said reinforcement member is formed from a thin sheet of a metal selected from the group consisting of stainless steel, platinum-iridium alloy, molybdenum-rhenium alloy, tantalum, gold, and combinations thereof.

3. The stent of claim 1, wherein said polymer is a biodegradable polymer selected from the group consisting of poly-DL-lactic acid, poly-L-lactic acid, polyorthoesters, polyiminocarbonates, aliphatic polycarbonates, polyphosphazenes, and combinations thereof.

4. The stent of claim 1, wherein said polymer is a biodegradable polymer selected from the group consisting of poly-DL-lactic acid and poly-L-lactic acid.

5. The stent of claim 4, wherein said polymer absorbs a releasing therapeutic drug selected from the group consisting of heparin, methotrexate, angiopeptin and prostacyclin.

6. The stent of claim 1, wherein said reinforcement member is laminated on each of the side surfaces with a layer of said polymer to encapsulate the reinforcement member.

7. A stent for use in maintaining the patency of blood vessels, said stent comprising:

a metal reinforcement member having first and second side surfaces, said reinforcement member having first and second ends and a main body portion between the first and second ends, the first end having a surface extending in a plane end defining a slot for receiving the second end, the second end and the main body portion being insertable through said slot so as to form a loop, the second end and the main body portion having a plurality of apertures, and said slot in the first end having a corresponding plurality of teeth for releasably engaging said plurality of apertures to adjustably retain the second end and the main body portion in said slot, said plurality of teeth extending from said slot at an angle of about 45°

out of the plane of the first end of the reinforcement member, said reinforcement member being capable of being rolled up into a cylindrical configuration whereby the first end overlaps the second end, and whereby when said reinforcement member is in said cylindrical configuration, said slot and said means for releasably engaging said slot permit radial expansion of said reinforcement member and resist radial compression of said reinforcement member; and

at least one layer of a polymer bonded to at least one of the side surfaces of said reinforcement member, said polymer being capable of absorbing and releasing therapeutic drugs.

8. The stent of claim 7, wherein said reinforcement member is formed from a thin sheet of a metal selected from the group consisting of stainless steel, platinum-iridium alloy, molybdenum-rhenium alloy, tantalum, gold, and combinations thereof.

9. The stent of claim 7, wherein said polymer is a biodegradable polymer selected from the group consisting of poly-DL-lactic acid, poly-L-lactic acid, polyorthoesters, polyiminocarbonates, aliphatic polycarbonates, polyphosphazenes, and combinations thereof.

10. The stent of claim 7, wherein said polymer is a biodegradable polymer selected from the group consisting of poly-DL-lactic acid and poly-L-lactic acid.

11. The stent of claim 7, wherein said reinforcement member is laminated on each of the side surfaces with a layer of said polymer to encapsulate the reinforcement member.

12. A stent for use in maintaining the patency of blood vessels, the stent comprising:

a metal reinforcement member having first and second side surfaces, said reinforcement member having first and second ends and a main body portion between the first and second ends, said reinforcement member being capable of being rolled up into a cylindrical configuration whereby the first end overlaps the second end, said first end of the reinforcement member extending in a plane and comprising a surface defining a slot for receiving the second end, the second end and the main body portion being insertable through said slot so as to form a loop, said slot in the first end having means for releasably engaging the second end and the main body portion, and the second end and the main body portion having corresponding means for releasably engaging said slot to adjustably retain the second end and the main body portion in said slot, said means in the slot of the first end for releasably engaging the second end and main body portion comprising a plurality of teeth extending from said slot at an angle of about 45°

out of the plane of the first end of the reinforcement member, and said means of the second end and the main body portion for releasably engaging the slot comprising a plurality of apertures in the second end and the main body portion for receiving said teeth, whereby when said reinforcement member is in said cylindrical configuration, said slot and said means for releasably engaging said slot permit radial expansion of said reinforcement member and resist radial compression of said reinforcement member; and

at least one layer of a polymer bonded to at least one of the side surfaces of the reinforcement member, said polymer being capable of absorbing and releasing therapeutic drugs.