Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
First Claim
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1. The compound of Formula I ##STR21## wherein B is a base selected from the group consisting of xanthine, hypoxanthine, 8-bromoguanine, 8-chloroguanine, 8-aminoguanine, 8-hydrazinoguanine, 8-hydroxyguanine, 8-methylguanine, 8-thioguanine, 2-aminopurine, 2,6-diaminopurine, and 2-amino-6-methoxyethoxypurine;
- alk1 is C1-4 alkylene;
alk2 is independently selected from a chemical bond and C1-4 alkylene;
alk3 is a chemical bond;
Q and R2 are hydrogen;
R1 is independently selected from hydrogen and C1-4 alkyl and wherein one of R1 or alk2 are C1-4 alkyl or C1-4 alkylene respectively;
R3 and R4 are independently selected from hydrogen, C1-6 alkyl, phenyl, and phenyl-C1-4 -alkylene;
and the corresponding salts, and solvates thereof;
provided, however, that when B is 2-amino-6-methoxyethoxypurine then R3 and R4 are ethyl, alk2 is a bond, R1 is H and alk1 --C(R1)(alk2 Q)-alk3 is 1,3 propylene or 1,4 butylene.
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Abstract
A series of compounds of Formula I which have anti-tumor activity, and are useful in treating viral infections, their compositions and use. ##STR1## In Formula I B is a purine or pyrimidine base; alk1 alk2 and alk3 are chemical bonds or alkylene groups; Q is hydrogen or hydroxyl; and R1 -R4 are hydrogen or alkyl.
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Citations
11 Claims
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1. The compound of Formula I ##STR21## wherein B is a base selected from the group consisting of xanthine, hypoxanthine, 8-bromoguanine, 8-chloroguanine, 8-aminoguanine, 8-hydrazinoguanine, 8-hydroxyguanine, 8-methylguanine, 8-thioguanine, 2-aminopurine, 2,6-diaminopurine, and 2-amino-6-methoxyethoxypurine;
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alk1 is C1-4 alkylene; alk2 is independently selected from a chemical bond and C1-4 alkylene; alk3 is a chemical bond; Q and R2 are hydrogen; R1 is independently selected from hydrogen and C1-4 alkyl and wherein one of R1 or alk2 are C1-4 alkyl or C1-4 alkylene respectively; R3 and R4 are independently selected from hydrogen, C1-6 alkyl, phenyl, and phenyl-C1-4 -alkylene; and the corresponding salts, and solvates thereof;
provided, however, that when B is 2-amino-6-methoxyethoxypurine then R3 and R4 are ethyl, alk2 is a bond, R1 is H and alk1 --C(R1)(alk2 Q)-alk3 is 1,3 propylene or 1,4 butylene. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification
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Current AssigneeInstitute Of Organic Chemistry And Biochemistry Of The Ascr, V.V.I., REGA Stichting VZW
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Original AssigneeInstitute Of Organic Chemistry And Biochemistry Of The Ascr, V.V.I., REGA Stichting VZW
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InventorsBronson, Joanne J., Martin, John C., Webb, Robert W. II
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Primary Examiner(s)Berch, Mark L.
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Application NumberUS07/829,784Time in Patent Office1,999 DaysField of Search514/81, 514/86, 544/243, 544/244US Class Current544/244CPC Class CodesC07F 9/65616 containing the ring system ...
