Detection of oscillometeric blood pressure complexes using correlation

• US 5,651,370 A
• Filed: 08/13/1996
• Issued: 07/29/1997
• Est. Priority Date: 02/15/1995
• Status: Expired due to Fees

• Current Assignee: Critikon Co. LLC
• Original Assignee: Johnson & Johnson Medical Incorporated (Johnson & Johnson)
• Inventors: Hersh, Lawrence T., Booth, John W.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US08/696,053
• Time in Patent Office: 350 Days
• Field of Search: 128/677, 128/680-683, 128/687, 364/413.03
• US Class Current: 600/494
• CPC Class Codes: A61B 5/02225 using the oscillometric method
• CPC Class Codes: A61B 5/0225 the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal

Abstract

An automated sphygmomanometer which stores the attributes for all oscillation complexes at each pressure step and compares the stored waveform data to a template containing the attributes of a "clean" oscillation complex from a present or previous NIBP determination or from a standard template determined from a broad population of patients. Preferably, an oscillation complex near MAP is selected as the template. After the oscillation complexes have been gathered, correlation values for each new oscillation complex in the stored waveform data and the template are calculated using correlation calculations from detection theory. All oscillation complexes which highly correlate with the template (their correlation values are above a given threshold) are maintained as "good" oscillation data, while the remainder of the oscillation complexes are ignored as corrupted by artifact data. Artifact-reduced data may then be used in the blood pressure calculation. Similar correlation techniques are also used at each pressure step in a real-time manner to detect the presence of an oscillation complex during a step inflate or deflate blood pressure measurement.

Claims

1. An automated sphygmomanometer apparatus, comprising:

an inflatable and deflatable pressure cuff;

inflating means operatively coupled to said cuff for selectively applying a medium under pressure to said cuff for inflating and pressurizing said cuff;

cuff pressure sensing means coupled to said cuff for sensing cuff pressure including any arterial blood pressure oscillations therein and outputting a cuff pressure signal;

deflating means operatively coupled to said cuff for selectively relieving pressure from said cuff;

control means for controlling said inflating means to inflate said cuff and said deflating means to deflate said cuff during respective blood pressure determinations of a patient at respective cuff pressure levels;

means for detecting said arterial blood pressure oscillations at respective cuff pressure levels during said respective blood pressure determinations of said patient, said detecting means including means for correlating said cuff pressure signal with a predetermined template representing attributes of a known arterial blood pressure oscillation and for determining the presence of an arterial blood pressure oscillation based on a result of said correlation; and

processing means for calculating a patient'"'"'s blood pressure from arterial blood pressure oscillations detected by said detecting means.

2. An apparatus as in claim 1, wherein said predetermined template corresponds to an arterial blood pressure oscillation waveform of said patient measured near mean arterial pressure during a previous blood pressure determination of said patient.

3. An apparatus as in claim 1, wherein said predetermined template corresponds to an arterial blood pressure oscillation waveform of said patient measured at one of said respective cuff pressure levels of a current blood pressure determination of said patient.

4. An apparatus as in claim 1, wherein said predetermined template corresponds to a standard arterial blood pressure oscillation waveform which is adjusted to each patient as a function of the patient'"'"'s heart rate.

5. An apparatus as in claim 1, wherein said predetermined template corresponds to a previously measured arterial blood pressure oscillation waveform of said patient and said predetermined template is updated to a new template for said patient during a blood pressure determination of said patient.

6. An apparatus as in claim 1, wherein said detecting means calculates correlation values C_i indicating a degree of correlation of samples of said cuff pressure signal, W_i, with said predetermined template, T_i.

7. An apparatus as in claim 6, wherein said detecting means calculates said correlation values C_i, -1<

=C_i <

=+1, in accordance with the equation;

##EQU2## and where i and j are time indices, n is a number of samples in said predetermined template, and the summations are from 1 to n.

8. An apparatus as in claim 7, wherein said detecting means compares said correlation values C_i with a predetermined threshold L, -1<

=L<

=+1, and determines that an arterial blood pressure oscillation is present when C_i >

L.

9. An apparatus as in claim 8, wherein said detecting means adjusts said predetermined threshold L during a blood pressure determination of said patient.

10. An apparatus as in claim 9, wherein said detecting means reduces said predetermined threshold L during said blood pressure determination of said patient until a sufficient number of arterial blood pressure oscillations to form an oscillometric envelope are found.

11. An apparatus as in claim 6 wherein said detecting means calculates said correlation values C_i in accordance with the equation:

space="preserve" listing-type="equation">C.sub.j =Σ

W.sub.i+j ·

T.sub.i

where i and j are time indices and the summation is i from 1 to n.

12. An apparatus as in claim 11, wherein said detecting means compares said correlation values C_i with a predetermined threshold L, where L is a function of the energy levels of W_i, T_i and noise, and determines that an arterial blood pressure oscillation is present when C_i >

L.

13. An apparatus as in claim 12, wherein said detecting means adjusts said predetermined threshold L during a blood pressure determination of said patient.

14. An apparatus as in claim 13, wherein said detecting means reduces said predetermined threshold L during said blood pressure determination of said patient until a sufficient number of arterial blood pressure oscillations to form an oscillometric envelope are found.

15. A method of determining a patient'"'"'s blood pressure using an automatic oscillometric blood pressure monitor comprising a cuff, means for inflating and deflating said cuff, means for measuring arterial blood pressure oscillation complexes through measurement of time varying pressures within said cuff, and means for searching for arterial blood pressure oscillation complexes at respective cuff pressure levels, said method of determining a patient'"'"'s blood pressure comprising the steps of:

(a) selectively inflating and deflating said cuff to a cuff pressure level in order to search for arterial blood pressure oscillation complexes of said patient;

(b) detecting said arterial blood pressure oscillations at said cuff pressure level by correlating samples of an output signal from said arterial blood pressure oscillation complex measuring means with a predetermined template representing attributes of a known arterial blood pressure oscillation, and by determining the presence of an arterial blood pressure oscillation complex based on a result of said correlation;

(c) repeating steps (a) and (b) for subsequent cuff pressure levels until an oscillometric envelope of arterial blood pressure oscillation complexes has been determined; and

(d) calculating a patient'"'"'s blood pressure from said oscillometric envelope.

16. A method as in claim 15, wherein said detecting step (b) comprises the steps of:

calculating a correlation value for a moving time window of samples of said output signal indicating a degree of correlation between said predetermined template and samples of said output signal in said moving time window;

identifying time windows for which said predetermined template and said samples of said output signal have correlation values above a predetermined threshold; and

storing arterial blood pressure complexes from said time windows for use in said blood pressure calculating step (d).

17. A method as in claim 16, comprising the further step of identifying said predetermined template as an arterial blood pressure oscillation waveform of said patient measured near mean arterial pressure during a previous blood pressure determination of said patient.

18. A method as in claim 16, comprising the further step of identifying said predetermined template as an arterial blood pressure oscillation waveform of said patient measured at one of said respective cuff pressure levels of a current blood pressure determination of said patient.

19. A method as in claim 16, comprising the further step of identifying said predetermined template as a standard arterial blood pressure oscillation waveform which is adjusted to each patient as a function of the patient'"'"'s heart rate.

20. A method as in claim 16, comprising the further steps of identifying said predetermined template as a previously measured arterial blood pressure oscillation waveform of said patient and updating said predetermined template to a new template during a blood pressure determination of said patient.

21. A method as in claim 16, wherein said correlation value calculating step comprises the step of calculating correlation values C_i indicating a degree of correlation of said samples of said output signal, W_i, with said predetermined template, T_i.

22. A method as in claim 21, wherein said correlation value calculating step comprises the step of calculating said correlation values C_i, -1<

=C_i <

=+1, in accordance with the equation;

##EQU3## and where i and j are time indices, n is a number of samples in said predetermined template, and the summations are from 1 to n.

23. A method in claim 22, wherein said time windows identifying step comprises the steps of comparing said correlation values C_i with a predetermined threshold L, -1<

=L<

=+1, and determining that an arterial blood pressure oscillation is present when C_i >

L.

24. A method as in claim 23, comprising the further step of adjusting said predetermined threshold L during a blood pressure determination of said patient.

25. A method as in claim 24, comprising the further step of reducing said predetermined threshold L during said blood pressure determination until a sufficient number of arterial blood pressure oscillations to form an oscillometric envelope are found.

26. A method as in claim 21, wherein said correlation value calculating step comprises the step of calculating said correlation values C_i in accordance with the equation:

space="preserve" listing-type="equation">C.sub.j =Σ

W.sub.i+j ·

T.sub.i

where i and j are time indices and the summation is i from 1 to n.

27. A method as in claim 26, wherein said time windows identifying step comprises the steps of comparing said correlation values C_i with a predetermined threshold L, where L is a function of the energy levels of W_i, T_i, and noise, and determining that an arterial blood pressure oscillation is present when C_i >

L.

28. A method as in claim 27, comprising the further step of adjusting said predetermined threshold L during a blood pressure determination of said patient.

29. A method as in claim 28, comprising the further step of reducing said predetermined threshold L during said blood pressure determination of said patient until a sufficient number of arterial blood pressure oscillations to form an oscillometric envelope are found.