Method of electrical impedance imaging using ionic metal chelates

• US 5,651,955 A
• Filed: 06/07/1995
• Issued: 07/29/1997
• Est. Priority Date: 01/03/1992
• Status: Expired due to Fees

• Current Assignee: Nycomed A/S (Takeda Pharmaceutical Company Limited)
• Original Assignee: Nycomed A/S (Takeda Pharmaceutical Company Limited)
• Inventors: Klaveness, Jo
• Primary Examiner(s): Hollinden, Gary E.
• Application Number:
  US08/482,082
• Time in Patent Office: 783 Days
• Field of Search: 424/9.36, 424/9.363, 424/9.364, 424/9.365, 514/184, 514/492, 514/502, 514/836, 436/173, 128/653.4, 128/654
• US Class Current: 424/9.36
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: Y10T 436/24 Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

A method of electrical impedance imaging (EII) of a subject comprising administering an EII sensitive contrast agent and generating an electrical impedance image of at least part of the subject.

Claims

1. A method of electrical impedance imaging of a human or animal subject which method comprises parenterally administering to said subject an EII contrast agent, optionally dissolved or dispersed in a physiologically tolerable liquid carrier medium and generating an electrical impedance image of at least part of said subject, said contrast agent being capable on dispersion in water of yielding a fluid having an electrical impedance different to that of water and being a physiologically tolerable material wherein said contrast agent comprises an ionic metal chelate.

2. A method as claimed in claim 1 wherein said contrast agent comprises a blood pool agent.

3. A method as claimed in claim 1 wherein said ionic metal chelate is an MR contrast agent.

4. A method as claimed in claim 1 wherein said ionic metal chelate is MnDPDP, GdDTPA or GdDOTA or a derivative thereof.

5. A method as claimed in claim 1 wherein said ionic metal chelate is the salt of a paramagnetic metal chelate complex or the salt of a diamagnetic metal chelate complex.

6. A method as claimed in claim 5 wherein said paramagnetic metal chelate complex comprises a metal ion selected from the group consisting of anions of Gd, Dy, Eu, Mo, Fe, Cr and Mn.