Apparatus and method for delivering a biologically active compound into a biological environment

• US 5,651,979 A
• Filed: 06/07/1995
• Issued: 07/29/1997
• Est. Priority Date: 03/30/1995
• Status: Expired due to Fees

• Current Assignee: Advanced Medical Solutions (Plymouth) Ltd.
• Original Assignee: Gel Sciences, Inc. (Advanced Medical Solutions Group Plc)
• Inventors: Ron, Eyal S., Roos, Eric, Schiller, Matthew E.
• Primary Examiner(s): Azpuru, Carlos
• Application Number:
  US08/473,218
• Time in Patent Office: 783 Days
• Field of Search: 604/892.1, 604/891.1, 424/423
• US Class Current: 424/423
• CPC Class Codes: A61K 38/47 acting on glycosyl compounds (3.2), e.g. cellulases, lactases
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/2054 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61L 15/60 Liquid-swellable gel-forming materials, e.g. super-absorbents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 26/008 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: C08B 15/005 Crosslinking of cellulose derivatives
• CPC Class Codes: C08B 31/003 Crosslinking of starch
• CPC Class Codes: C08B 31/006 Crosslinking of derivatives of starch
• CPC Class Codes: C12N 2533/30 Synthetic polymers
• CPC Class Codes: C12N 2533/78 Cellulose
• CPC Class Codes: C12N 5/0068 General culture methods using substrates for specific animal cell type C12N5/06

Abstract

System for delivery of a biologically active substance into an environment. First and second chambers are separated by a moveable partition. The first chamber includes a polymer gel network which undergoes a volume change in response to an environmental condition such as pH. The first compartment includes a screen or membrane for confining the polymer gel network while allowing communication with fluid in an environment. The second compartment contains a biologically active compound or drug which is delivered to the environment through an orifice in the second compartment. Upon the occurrence of the triggering environmental condition, the polymer gel network undergoes a volume change which moves the moveable partition expelling the drug through the orifice. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met.

Claims

1. Apparatus for controlled delivery of a biologically active compound to a biological environment comprising:

first and second compartments separated by a moveable partition;

the first compartment including a screen or membrane forming at least a portion of a side of the first compartment, the first compartment containing a polymer gel network which undergoes a volume change in response to an environmental condition which varies in the biological environment;

the second compartment containing an effective amount of the biologically active compound and including an orifice communicating with the biological environment;

whereupon volume change of the polymer gel network moves the partition and causes the biologically active compound to be discharged into the biological environment through the orifice.

2. The apparatus of claim 1 wherein the environmental condition is pH.

3. The apparatus of claim 1 wherein the polymer gel network is in a collapsed state at low pH and in an expanded state had a high pH.

4. The apparatus of claim 1 wherein the polymer gel network has a known acceptable toxicological profile.

5. The apparatus of claim 1 wherein the crosslinked polymer gel network comprises a polymer selected from the group consisting of hydroxypropylcellulose, hydropropylmethylcellulose, starch, and hydroxyethylcellulose.

6. The apparatus of claim 1 wherein the environmental condition is selected from the group comprising:

temperature, solvent composition, pH, electric field, magnetic field, light intensity, light wavelength, pressure, ionic strength, osmolarity, and electric current.

7. The apparatus of claim 1 wherein the polymer gel network is a responsive gel network.

8. The apparatus of claim 7 wherein the responsive gel network exhibits a continuous volume change.

9. The apparatus of claim 7 wherein the responsive gel network exhibits a discontinuous volume change.

10. Apparatus for controlled delivery of a composition comprising:

a compartment containing the composition; and

a polymer gel adapted to undergo a volume change in response to a preselected physical condition;

the volume change causing the composition to be expelled from the compartment.

11. Apparatus of claim 10 wherein the compartment is implanted into a body.

12. Apparatus of claim 10 wherein the compartment is external to the body.