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Ulcer prevention and treatment composition

  • US 5,651,987 A
  • Filed: 08/27/1993
  • Issued: 07/29/1997
  • Est. Priority Date: 12/17/1991
  • Status: Expired due to Fees
First Claim
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1. An anti-ulcer composition having rapid delivery and enhanced adherence to ulcer-bearing tissue comprising:

  • a solid matrix having suspended therein an anti-ulcer medicament, said matrix formed by flash-flow melt-spinning a mixture ofi) a melt-spinnable carrier material present in an amount sufficient to form a flash-flow melt-spun matrix when said anti-ulcer medicament is dispersed therein;

    ii) an anti-ulcer medicament present in an amount sufficient to achieve a therapeutic effect; and

    iii) a hydrogel in addition to said carrier material, said hydrogel being selected from the group consisting of gums, cellulose, pectins, gelatin, polycarbophil, alginate and mixtures thereof to provide mucosal adherence.

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