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Genetically engineered mammalian neural crest stem cells

  • US 5,654,183 A
  • Filed: 01/28/1994
  • Issued: 08/05/1997
  • Est. Priority Date: 07/27/1992
  • Status: Expired due to Term
First Claim
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1. An isolated cellular composition of genetically-engineered mammalian neural crest stem cells which are capable of self-renewal in a feeder cell-independent culture medium or glial cells, wherein said genetically engineered neural crest stem cells express low-affinity nerve growth factor receptor (LNGFR) and nestin, but do not express neuronal or glial lineage markers including glial fibrillary acidic protein (GFAP), wherein at least one neural crest stem cell of said isolated composition is capable of differentiation to a peripheral nervous system neuronal cell that does not express LNGFR or nestin but does express neurofilament-160, and wherein at least one neural crest stem cell of said isolated composition is capable of differentiation to a peripheral nervous system glial cell that expresses LNGFR, nestin and GFAP.

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