Antiarrhythmic agent

• US 5,654,317 A
• Filed: 03/17/1995
• Issued: 08/05/1997
• Est. Priority Date: 09/18/1992
• Status: Expired due to Fees

• Current Assignee: Otsuka Pharmaceutical Company Limited (Otsuka Holdings Company Limited)
• Original Assignee: Otsuka Pharmaceutical Company Limited (Otsuka Holdings Company Limited)
• Inventors: Tominaga, Michiaki, Yabuuchi, Yoichi, Teramoto, Shuji, Fujioka, Takafumi
• Primary Examiner(s): Bleutge, John C.
• Assistant Examiner(s): Harrison, Robert H.
• Application Number:
  US08/403,891
• Time in Patent Office: 872 Days
• Field of Search: 514/312, 514/314, 514/350, 546/157
• US Class Current: 514/312
• CPC Class Codes: A61K 31/47 Quinolines; Isoquinolines
• CPC Class Codes: A61K 31/4704 2-Quinolinones, e.g. carbostyril

Abstract

An antiarrhythmic agent which comprises as an active ingredient a carbostyril derivative of the formula: ##STR1## wherein R₁ is hydrogen atom or a lower alkyl group, and R₂ is a phenyl-lower alkyl group which has optionally 1 to 3 substituents of a lower alkoxy group on the phenyl ring, or a pharmaceutically acceptable salt thereof.

Claims

1. A method for the prophylaxis or treatment of ventricular tachycardia, which comprises administering an effective amount of a carbostyril derivative of the following formula (1) or a pharmaceutically acceptable salt thereof:

##STR3## wherein R₁ is a hydrogen atom, and R₂ is a phenyl (C₁ -C₆) alkyl group which has optionally 1 to 3 substituents of a (C₁ -C₆) alkoxy group on the phenyl ring, to a subject suffering from ventricular tachycardia, wherein said carbostyril derivative of formula (I) is 6-[3-(3,4-dimethoxybenzyl)amino-2-hydroxypropoxy]-carbostyril.