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Method for non-invasive blood analyte measurement with improved optical interface

  • US 5,655,530 A
  • Filed: 08/09/1995
  • Issued: 08/12/1997
  • Est. Priority Date: 08/09/1995
  • Status: Expired due to Term
First Claim
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1. A non-invasive method for measuring the concentration of a blood analyte in human tissue comprising the steps of:

  • (a) providing an apparatus for measuring infrared absorption, said apparatus including an energy source emitting infrared energy at multiple wavelengths operatively connected to an input element of a sensor element, said apparatus further including an output element within said sensor element operatively connected to a spectrum analyzer;

    (b) selecting a sample area on a skin surface of an analyte-containing human tissue;

    (c) providing an index-matching medium and disposing a quantity of said medium between said sensor element and said sample area, wherein said index-matching medium comprises a mixture of perfluorocarbons and chlorofluorocarbons;

    (d) placing said input element and said output element in contact with said quantity of index-matching medium to couple said sensor element with said analyte-containing tissue through said index-matching medium; and

    (e) irradiating said analyte-containing tissue through said input element so that there is differential absorption of at least some of said wavelengths and measuring said differential absorption of said wavelengths through said output element connected to said spectrum analyzer.

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