Noninvasive method for identifying coronary artery disease utilizing electrocardiography derived data
First Claim
1. A noninvasive method of investigating cardiac status of a subject and enabling classification of a subject into normal and abnormal cardiac categories utilizing electrocardiography (ECG) data obtained therefrom, said method comprising, in a functional sequence, performance of the steps of:
- a. obtaining data from (ECG) cycle(s) from each of a multiplicity of members of a population of subjects who have been documented as normal subjects, in that they do not show risk factors for, or demonstrate detectable cardiac abnormality, by monitoring at least one lead(s) of an (ECG) system;
b. selecting some (ECG) cycle portion, and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s) by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for (ECG) cycle(s) obtained from each of a number of members of said multiplicity of members of a population of subjects who have been documented as normal subjects, each said calculated average selected (ECG) cycle portion data set being a composite data set of said selected (ECG) cycle portion for said population of normal subjects, for a monitored (ECG) system lead;
c. obtaining data from (ECG) cycle(s) from a subject, by monitoring at least one lead(s) of an (ECG) system, said (ECG) system lead(s) monitored being the same as the monitored (ECG) system lead(s) utilized in step a. to obtain data utilized in step b.;
d. selecting some (ECG) cycle portion, which is the same as that selected in step b., and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s) by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for (ECG) cycle(s) obtained from said subject, each said calculated average selected (ECG) cycle portion data set being a composite data set of said selected (ECG) cycle portion for said subject, for a monitored (ECG) system lead;
e. calculating corresponding representative parameter(s) from resulting composite data sets calculated in steps b. and d., for monitored (ECG) system lead(s), for, respectively, said normal subject population and said subject;
f. comparing subject to corresponding normal subject population representative parameter(s), and combining results thereof to arrive at a "score", the magnitude of which "score" results from difference(s) between magnitude(s) of corresponding normal subject population, and subject representative parameter(s), which "score" magnitude increases when said difference(s) in magnitude(s) between corresponding normal subject population, and subject, representative parameter(s) increase, the magnitude of which "score" provides an indication of the cardiac status of said subject, with a "score" near zero being indicative of a subject properly categorized as a cardiac normal in that the magnitude(s) of subject representative parameter(s) are generally more closely matched to the magnitude(s) of corresponding normal subject population representative parameter(s), and with a progressively higher "score" being indicative of a subject progressively more properly categorized as a cardiac abnormal in that the magnitude(s) of subject representative parameter(s) are generally progressively less closely matched to the magnitude(s) of corresponding normal subject population representative parameter(s).
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Abstract
A method of analyzing empirically derived electrocardiograph (ECG) data which allows surprisingly accurate catagorization of subjects into various abnormal and normal classifications is disclosed. The presently preferred embodiment of the present invention applies an algorithm which compares root-mean-square (RMS) mean values derived from analysis of a representative composite of selected portions of a number of ECG PQRST waveforms obtained from (ECG) investigation of a subject, to similarly derived RMS mean and RMS standard deviation values present in a compiled data bank derived from (ECG) investigation of numerous normals, in each of a plurality of frequency range bands. A highly diagnostic numerical "Score" is calculated by addition of "Score" components found to be acceptable under certain mathematical criteria, and provided by the algorithm. Visually interpretable power spectral density plots supplement the method.
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Citations
31 Claims
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1. A noninvasive method of investigating cardiac status of a subject and enabling classification of a subject into normal and abnormal cardiac categories utilizing electrocardiography (ECG) data obtained therefrom, said method comprising, in a functional sequence, performance of the steps of:
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a. obtaining data from (ECG) cycle(s) from each of a multiplicity of members of a population of subjects who have been documented as normal subjects, in that they do not show risk factors for, or demonstrate detectable cardiac abnormality, by monitoring at least one lead(s) of an (ECG) system; b. selecting some (ECG) cycle portion, and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s) by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for (ECG) cycle(s) obtained from each of a number of members of said multiplicity of members of a population of subjects who have been documented as normal subjects, each said calculated average selected (ECG) cycle portion data set being a composite data set of said selected (ECG) cycle portion for said population of normal subjects, for a monitored (ECG) system lead; c. obtaining data from (ECG) cycle(s) from a subject, by monitoring at least one lead(s) of an (ECG) system, said (ECG) system lead(s) monitored being the same as the monitored (ECG) system lead(s) utilized in step a. to obtain data utilized in step b.; d. selecting some (ECG) cycle portion, which is the same as that selected in step b., and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s) by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for (ECG) cycle(s) obtained from said subject, each said calculated average selected (ECG) cycle portion data set being a composite data set of said selected (ECG) cycle portion for said subject, for a monitored (ECG) system lead; e. calculating corresponding representative parameter(s) from resulting composite data sets calculated in steps b. and d., for monitored (ECG) system lead(s), for, respectively, said normal subject population and said subject; f. comparing subject to corresponding normal subject population representative parameter(s), and combining results thereof to arrive at a "score", the magnitude of which "score" results from difference(s) between magnitude(s) of corresponding normal subject population, and subject representative parameter(s), which "score" magnitude increases when said difference(s) in magnitude(s) between corresponding normal subject population, and subject, representative parameter(s) increase, the magnitude of which "score" provides an indication of the cardiac status of said subject, with a "score" near zero being indicative of a subject properly categorized as a cardiac normal in that the magnitude(s) of subject representative parameter(s) are generally more closely matched to the magnitude(s) of corresponding normal subject population representative parameter(s), and with a progressively higher "score" being indicative of a subject progressively more properly categorized as a cardiac abnormal in that the magnitude(s) of subject representative parameter(s) are generally progressively less closely matched to the magnitude(s) of corresponding normal subject population representative parameter(s). - View Dependent Claims (2, 3, 4, 5, 6)
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7. A noninvasive method of investigating cardiac status of a subject and enabling classification of a subject into normal and abnormal cardiac categories utilizing electrocardiography (ECG) data obtained therefrom, said method comprising, in a functional sequence, performance of the steps of:
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a. obtaining data from (ECG) cycle(s) from each of a multiplicity of members of a population of subjects who have been documented as normal subjects, in that they do not show risk factors for, or demonstrate detectable cardiac abnormality, by monitoring at least one leads) of an (ECG) system; b. selecting some (ECG) cycle portion, and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s) by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for (ECG) cycle(s) obtained from each of a number of members of said multiplicity of members of a population of subjects who have been documented as normal subjects, each said calculated average selected (ECG) cycle portion data set being a composite data set of said selected (ECG) cycle portion for said population of normal subjects, for a monitored (ECG) system lead; c. obtaining data from (ECG) cycle(s) from a subject, by monitoring at least one lead(s) of an (ECG) system, said (ECG) system lead(s) monitored being the same as the monitored (ECG) system lead(s) utilized in step a. to obtain data utilized in step b.; d. selecting some (ECG) cycle portion, which is the same as that selected in step b., and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s) by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for (ECG) cycle(s) obtained from said subject, each said calculated average selected (ECG) cycle portion data set being a composite data set of said selected (ECG) cycle portion for said subject, for a monitored (ECG) system lead; e. calculating corresponding representative parameter(s) and corresponding ratio(s) involving representative parameters from resulting composite data sets calculated in steps b. and d., for monitored (ECG) system lead(s), for, respectively, said normal subject population and said subject; f. comparing specific ratio(s) of subject to corresponding specific ratio(s) of normal subject population representative parameters, and combining results thereof to arrive at a "score", the magnitude of which "score" results from difference(s) between magnitude(s) of specific corresponding ratio(s) of normal subject population, and ratio(s) of subject representative parameters, which "score" magnitude increases when said difference(s) in magnitude(s) between specific ratio(s) of corresponding normal subject population, and specific ratio(s) of subject representative parameters increase, the magnitude of which "score" provides an indication of the cardiac status of said subject, with a "score" near zero being indicative of a subject properly categorized as a cardiac normal in that the magnitude(s) of ratio(s) of subject representative parameters are generally more closely matched to the magnitude(s) of corresponding ratio(s) of normal subject population representative parameters, and with a progressively higher "score" being indicative of a subject progressively more properly categorized as a cardiac abnormal in that the magnitude(s) of ratio(s) of subject representative parameters are generally progressively less closely matched to the magnitude(s) of ratio(s) of corresponding normal subject population representative parameters. - View Dependent Claims (8, 9, 10)
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11. A noninvasive method of investigating cardiac status of a subject and enabling classification of a subject into normal and abnormal cardiac categories utilizing electrocardiography (ECG) data obtained therefrom, said method comprising, in a functional sequence, performance of the steps of:
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a. obtaining data from (ECG) cycle(s) from each of a multiplicity of members of a population of subjects who have been documented as normal subjects, in that they do not show risk factors for, or demonstrate detectable cardiac abnormality, by monitoring at least one lead(s) of an (ECG) system; b. selecting some (ECG) cycle portion and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s), by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for (ECG) cycle(s) obtained from each of a number of said multiplicity of members of a population of subjects who have been documented as normal subjects, and selecting a plurality of frequency bands and applying filtering techniques, to provide a plurality of data sets for each said at least one (ECG) system lead(s) monitored, each said data set being a composite data set of said selected (ECG) cycle portion for said population of normal subjects in a monitored lead and selected frequency band range; c. obtaining data from (ECG) cycle(s) from a subject, by monitoring at least one lead(s) of an (ECG) system, said (ECG) system lead(s) monitored being the same as the monitored (ECG) system lead(s) utilized in step a. to obtain data utilized in step b.; d. selecting some (ECG) cycle portion, said (ECG) cycle portion being the same as that selected in step b. for said normal subject population, and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s), by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for subject (ECG) cycle(s), and selecting a plurality of frequency bands, said selected frequency bands being the same as those selected in step b. for said normal subject population, and applying filtering techniques which are the same as those applied in step b. for said normal subject population, to provide a plurality of data sets for each said at least one monitored (ECG) system lead(s), each said data set being a composite data set of said selected (ECG) cycle portion for said subject in a monitored lead and selected frequency band range; e. calculating corresponding representative parameter(s) from resulting composite data sets calculated in steps b. and d., in said selected frequency band ranges for monitored (ECG) system lead(s), for respectively, said normal subject population and said subject; f. comparing specific subject to specific normal subject population corresponding representative parameter(s), and combining results thereof to arrive at a "score", the magnitude of which "score" results from difference(s) between magnitude(s) of corresponding normal subject population and subject representative parameter(s), which "score" magnitude increases when said difference(s) in magnitude(s) between corresponding normal subject population and subject representative parameter(s) increase, the magnitude of which "score" provides an indication of the cardiac status of said subject, with a "score" near zero being indicative of a subject properly categorized as a cardiac normal in that the magnitude(s) of subject representative parameter(s) are generally more closely matched to the magnitude(s) of corresponding normal subject population representative parameter(s), and with a progressively higher "score" being indicative of a subject progressively more properly categorized as a cardiac abnormal in that the magnitude(s) of subject representative parameter(s) are generally progressively less closely matched to the magnitude(s) of corresponding normal subject population representative parameter(s). - View Dependent Claims (12, 13, 14)
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15. A noninvasive method of investigating cardiac status of a subject and enabling classification of a subject into normal and abnormal cardiac categories utilizing electrocardiography (ECG) data obtained therefrom, said method comprising, in a functional sequence, performance of the steps of:
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a. obtaining data from (ECG) cycle(s) from each of a multiplicity of members of a population of subjects who have been documented as normal subjects, in that they do not show risk factors for, or demonstrate detectable cardiac abnormality, by monitoring at least one lead(s) of an (ECG) system; b. selecting some (ECG) cycle portion and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s), by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for (ECG) cycle(s) obtained from each of a number of said multiplicity of members of a population of subjects who have been documented as normal subjects, and selecting a plurality of frequency bands and applying filtering techniques, to provide a plurality of data sets for said at least one (ECG) system lead(s) monitored, each said data set being a composite data set of said selected (ECG) cycle portion for said population of normal subjects in a monitored lead and selected frequency band range; c. obtaining data from (ECG) cycle(s) from a subject, by monitoring at least one lead(s) of an (ECG) system, said (ECG) system lead(s) monitored being the same as the monitored (ECG) system lead(s) utilized in step a. to obtain data utilized in step b.; d. selecting some (ECG) cycle portion, said (ECG) cycle portion being the same as that selected in step b. for said normal subject population, and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s), by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for subject (ECG) cycle(s), and selecting a plurality of frequency bands, said selected frequency bands being the same as those selected in step b. for said normal subject population, and applying filtering techniques which are the same as those applied in step b. for said normal subject population, to provide a plurality of data sets for said at least one monitored (ECG) system lead(s), each said data set being a composite data set of said selected (ECG) cycle portion for said subject in a monitored lead and selected frequency band range; e. calculating corresponding representative parameter(s) and corresponding ratio(s) involving representative parameters from resulting composite data sets calculated in steps b. and d., in said selected frequency band ranges for monitored (ECG) system lead(s), for respectively, said normal subject population and said subject; f. comparing specific ratio(s) of subject to corresponding specific ratio(s) of normal subject population representative parameters, and combining results thereof to arrive at a "score", the magnitude of which "score" results from difference(s) between magnitude(s) of corresponding specific ratio(s) of normal subject population and specific ratio(s) of subject representative parameters, which "score" magnitude increases when said difference(s) in magnitude(s) between specific ratio(s) of corresponding normal subject population and subject representative parameters increase, the magnitude of which "score" provides an indication of the cardiac status of said subject, with a "score" near zero being indicative of a subject properly categorized as a cardiac normal in that the magnitude(s) Of ratio(s) of subject representative parameters are generally more closely matched to the magnitude(s) of corresponding ratio(s) of normal subject population representative parameters, and with a progressively higher "score" being indicative of a subject progressively more properly categorized as a cardiac abnormal in that the magnitude(s) of ratio(s) of subject representative parameters are generally progressively less closely matched to the magnitude(s) of ratio(s) of corresponding normal subject population representative parameters. - View Dependent Claims (16, 17, 18)
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19. A noninvasive method of investigating cardiac status of a subject and enabling classification of a subject into normal and abnormal cardiac categories utilizing electrocardiography (ECG) data obtained therefrom, said method comprising, in a functional sequence, performance of the steps of:
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a. obtaining data from (ECG) cycle(s) from each of a multiplicity of members of a population of subjects who have been documented as normal subjects, in that they do not show risk factors for, or demonstrate detectable cardiac abnormality, by monitoring at least one lead(s) of an (ECG) system; b. selecting some (ECG) cycle portion and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s), by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for (ECG) cycle(s) obtained from each of a number of said multiplicity of members of a population of subjects who have been documented as normal subjects, and selecting a plurality of frequency bands and applying filtering techniques, to provide a plurality of data sets for said at least one (ECG) system lead(s) monitored, each said data set being a composite data set of said selected (ECG) cycle portion for said population of normal subjects in a monitored lead and selected frequency band range; c. obtaining data from (ECG) cycle(s) from a subject, by monitoring at least one lead(s) of an (ECG) system, said (ECG) system lead(s) monitored being the same as the monitored (ECG) system lead(s) utilized in step a. to obtain data utilized in step b.; d. selecting some (ECG) cycle portion, said (ECG) cycle portion being the same as that selected in step b. for said normal subject population, and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s), by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for subject (ECG) cycle(s), and selecting a plurality of frequency bands, said selected frequency bands being the same as those selected in step b. for said normal subject population, and applying filtering techniques which are the same as those applied in step b. for said normal subject population, to provide a plurality of data sets for said at least one monitored (ECG) system lead(s), each said data set being a composite data set of said selected (ECG) cycle portion for said subject in a monitored lead and selected frequency band range; calculating corresponding representative parameter(s) and corresponding ratio(s) involving representative parameters from resulting composite data sets calculated in steps b. and d., in said selected frequency band ranges for monitored (ECG) system lead(s), for respectively, said normal subject population and said subject; f. comparing specific subject and corresponding specific normal subject population representative parameter(s), and combining results thereof with the results of comparing specific ration(s) of subject to corresponding specific ratio(s) of normal subject population representative parameters, to arrive at a "score", the magnitude of which "score" results from difference(s) in magnitude(s) between corresponding subject and normal subject population representative parameter(s) and difference(s) between magnitude(s) of corresponding ratio(s) of normal subject population, and ratio(s) of subject representative parameters, which "score" magnitude increases when difference(s) in magnitude(s) between corresponding subject and normal subject population representative parameter(s) increase and difference(s) in magnitude(s) between ratio(s) of corresponding normal subject population, and ratio(s) of subject representative parameters increase, the magnitude of which "score" provides an indication of the cardiac status of said subject, with a "score" near zero being indicative of a subject properly categorized as a cardiac normal in that magnitude(s) of subject representative parameter(s) are generally more closely matched to the magnitude(s) of corresponding normal subject population representative parameter(s) and magnitude(s) of ratio(s) of subject representative parameters are generally more closely matched to the magnitude(s) of corresponding ratio(s) of normal subject population representative parameters, and with a progressively higher "score" being indicative of a subject progressively more properly categorized as a cardiac abnormal in that magnitude(s) of subject representative parameter(s) are generally progressively less closely matched to the magnitude(s) of corresponding normal subject population representative parameter(s) and magnitude(s),of ratio(s) of subject representative parameter(s) are generally progressively less closely matched to the magnitude(s) of ratio(s) of corresponding normal subject population representative parameters. - View Dependent Claims (20, 21, 22)
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23. A noninvasive method of investigating cardiac status of a subject and enabling classification of a subject into normal and abnormal cardiac categories utilizing electrocardiography (ECG) data obtained therefrom, said method comprising, in a functional sequence, performance of the steps of:
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a. obtaining (ECG) data from (ECG) cycle(s) at each lead of a three lead Frank X-Y-Z (ECG) system, from each of a multiplicity of subjects who have been documented as normal subjects, in that they do not show risk factors for, or demonstrate detectable cardiac abnormality; b. selecting the QRS portion of said obtained (ECG) cycle(s) obtained from each Frank X-Y-Z (ECG) system lead and calculating an average selected QRS cycle portion data set for each monitored Frank (X-Y-Z) (ECG) system lead, by, for each Frank (X-Y-Z) (ECG) system lead, a procedure comprising combining corresponding QRS cycle portion data points for said selected QRS cycle portion for (ECG) cycle(s) obtained from each of a number of members of said multiplicity of members of a population of subjects who have been documented as normal subjects, and selecting a plurality of frequency bands and applying filtering techniques, to provide a plurality of data sets for each Frank X-Y-Z (ECG) system lead, each said data set being a composite QRS data set for said population of normal subjects, for a Frank (X-Y-Z) (ECG) system lead, in a selected frequency band range; c. obtaining (ECG) data from (ECG), cycle(s) from each Frank X-Y-Z (ECG) system lead for a subject; d. selecting the QRS complex of said obtained (ECG) cycle(s) obtained at each Frank X-Y-Z (ECG) system lead, said (ECG) QRS cycle portion being the same as that selected in step b. for said normal subject population, and calculating an average selected QRS cycle portion data set for each monitored Frank (X-Y-Z) (ECG) system lead, by, for each Frank (X-Y-Z) (ECG) system lead, a procedure comprising combining corresponding QRS cycle portion data points for said selected QRS cycle portion for subject (ECG) cycle(s), and selecting a plurality of frequency bands, said frequency bands being the same as those selected in step b. for said normal subject population and applying filtering techniques which are the same as those applied in step b. for said normal subject population, to provide a plurality of data sets for each Frank X-Y-Z (ECG) system lead, each said data set being a composite QRS data set for said subject, for a Frank (X-Y-Z) (ECG) system lead, in a selected frequency band range; e. calculating corresponding root-mean-square mean and root-mean-square standard deviation parameter(s) as well as corresponding ratio(s) involving root-mean-square and root-mean-square standard deviation parameters from resulting composite QRS data sets calculated in steps b. and d., in each selected frequency band range for each Frank X-Y-Z (ECG) system lead, for, respectively, said normal subject population and subject; f. comparing specific subject and corresponding specific normal subject population root-mean-square parameter(s), and combining results thereof with the results of comparing specific ratio(s) of subject to corresponding specific ratio(s) of normal subject population root-mean-square parameters, to arrive at a "score", the magnitude of which "score" results from difference(s) in magnitude(s) between corresponding subject and normal subject population root-mean-square parameter(s) and difference(s) between magnitude(s) of corresponding ratio(s) of normal subject population, and ratio(s) of subject root-mean-square parameters, which "score" magnitude increases when difference(s) in magnitude(s) between corresponding subject and normal subject population root-mean-square parameter(s) increase and difference(s) in magnitude(s) between ratio(s) of corresponding normal subject population, and ratio(s) of subject root-mean-square parameters increase, the magnitude of which "score" provides an indication of the cardiac status of said subject, with a "score" near zero being indicative of a subject properly categorized as a cardiac normal in that magnitude(s) of subject root-mean-square parameter(s) are generally more closely matched to the magnitude(s) of corresponding normal subject population root-mean-square parameter(s) and magnitude(s) of ratio(s) of subject root-mean-square parameters are generally more closely matched to the magnitude(s) of corresponding ratio(s) of normal subject population root-mean-square parameters, and with a progressively higher "score" being indicative of a subject progressively more properly categorized as a cardiac abnormal in that magnitude(s) of subject root-mean-square parameter(s) are generally progressively less closely matched to the magnitude(s) of corresponding normal subject population root-mean-square parameter(s) and magnitude(s) of ratio(s) of subject root-mean-square parameter(s) are generally progressively less closely matched to the magnitude(s) of ratio(s) of corresponding normal subject population root-mean-square parameters. - View Dependent Claims (24, 25, 26, 27, 28, 29)
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30. A noninvasive method of investigating cardiac status of a subject and enabling classification of a subject into normal and abnormal cardiac categories utilizing electrocardiography (ECG) data obtained therefrom, said method comprising, in a functional sequence, performance of the steps of:
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a. obtaining data from (ECG) cycle(s) from each of a multiplicity of members of a population of subjects who have been documented as normal subjects, in that they do not show risk factors for, or demonstrate detectable cardiac abnormality, by monitoring at least one lead(s) of an (ECG) system; b. selecting some (ECG) cycle portion and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s), by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for (ECG) cycle(s) obtained from each of a number of said multiplicity of members of a population of subjects who have been documented as normal subjects, and selecting a plurality of frequency bands and applying filtering techniques, to provide a plurality of data sets for said at least one (ECG) system lead(s) monitored, each said data set being a composite data set of said selected (ECG) cycle portion for said population of normal subjects in a monitored lead and selected frequency band range; c. obtaining data from (ECG) cycle(s) from a subject, by monitoring at least one lead(s) of an (ECG) system, said (ECG) system lead(s) monitored being the same as the monitored (ECG) system lead(s) utilized in step a. to obtain data utilized in step b.; d. selecting some (ECG) cycle portion, said (ECG) cycle portion being the same as that selected in step b. for said normal subject population, and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s), by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for subject (ECG) cycle(s), and selecting a plurality of frequency bands, said selected frequency bands being the same as those selected in step b. for said normal subject population, and applying filtering techniques which are the same as those applied in step b. for said normal subject population, to provide a purality of data sets for said at least one monitored (ECG) system lead(s), each said data set being a composite data set of said selected (ECG) cycle portion for said subject in a monitored lead and selected frequency band range; e. performing at least one of the following steps f. and g.; f. calculating mean and standard deviation representative parameters from at least one resulting composite data set calculated in step b., said mean and standard deviation parameters being from a selected frequency band range for a monitored (ECG) system lead, and providing a coordinate system consisting of magnitude vs. time on ordinate and abscissa respectively and plotting and displaying on said coordinate system loci consisting of;
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31. normal subject population standard deviation bounds located above and below said normal subject population mean, anda corresponding subject data set,
then observing differences between normal subject population and subject data plots, with a subject data set falling within the normal subject standard deviation bounds being indicative of a subject properly classified as a cardiac normal, and with a subject data set falling progressively further outside said normal subject standard deviation bounds being indicative of a subject progressively more properly classified as a cardiac abnormal; g. calculating power spectral density data for at least one resulting composite data set calculated in step b. and for a corresponding resulting composite data set calculated in step d. for a selected frequency band range for a monitored (ECG) system lead, and providing a coordinate system consisting of magnitude vs. frequency on ordinate and abscissa respectively and plotting and displaying on said coordinate system power spectral density data loci, then observing differences between normal subject population and subject data loci, with closely matched corresponding subject and normal subject population data set power spectral density loci being indicative of a subject properly classified as a cardiac normal and with progressively more mismatched subject and normal subject population data set power spectral density loci being indicative of a subject progressively more properly classified as a cardiac abnormal.
Specification