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Noninvasive method for identifying coronary artery disease utilizing electrocardiography derived data

  • US 5,655,540 A
  • Filed: 04/06/1995
  • Issued: 08/12/1997
  • Est. Priority Date: 04/06/1995
  • Status: Expired due to Term
First Claim
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1. A noninvasive method of investigating cardiac status of a subject and enabling classification of a subject into normal and abnormal cardiac categories utilizing electrocardiography (ECG) data obtained therefrom, said method comprising, in a functional sequence, performance of the steps of:

  • a. obtaining data from (ECG) cycle(s) from each of a multiplicity of members of a population of subjects who have been documented as normal subjects, in that they do not show risk factors for, or demonstrate detectable cardiac abnormality, by monitoring at least one lead(s) of an (ECG) system;

    b. selecting some (ECG) cycle portion, and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s) by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for (ECG) cycle(s) obtained from each of a number of members of said multiplicity of members of a population of subjects who have been documented as normal subjects, each said calculated average selected (ECG) cycle portion data set being a composite data set of said selected (ECG) cycle portion for said population of normal subjects, for a monitored (ECG) system lead;

    c. obtaining data from (ECG) cycle(s) from a subject, by monitoring at least one lead(s) of an (ECG) system, said (ECG) system lead(s) monitored being the same as the monitored (ECG) system lead(s) utilized in step a. to obtain data utilized in step b.;

    d. selecting some (ECG) cycle portion, which is the same as that selected in step b., and calculating an average selected (ECG) cycle portion data set for at least one monitored (ECG) system lead(s) by, for a monitored (ECG) system lead, a procedure comprising combining corresponding (ECG) cycle portion data points for said selected (ECG) cycle portion for (ECG) cycle(s) obtained from said subject, each said calculated average selected (ECG) cycle portion data set being a composite data set of said selected (ECG) cycle portion for said subject, for a monitored (ECG) system lead;

    e. calculating corresponding representative parameter(s) from resulting composite data sets calculated in steps b. and d., for monitored (ECG) system lead(s), for, respectively, said normal subject population and said subject;

    f. comparing subject to corresponding normal subject population representative parameter(s), and combining results thereof to arrive at a "score", the magnitude of which "score" results from difference(s) between magnitude(s) of corresponding normal subject population, and subject representative parameter(s), which "score" magnitude increases when said difference(s) in magnitude(s) between corresponding normal subject population, and subject, representative parameter(s) increase, the magnitude of which "score" provides an indication of the cardiac status of said subject, with a "score" near zero being indicative of a subject properly categorized as a cardiac normal in that the magnitude(s) of subject representative parameter(s) are generally more closely matched to the magnitude(s) of corresponding normal subject population representative parameter(s), and with a progressively higher "score" being indicative of a subject progressively more properly categorized as a cardiac abnormal in that the magnitude(s) of subject representative parameter(s) are generally progressively less closely matched to the magnitude(s) of corresponding normal subject population representative parameter(s).

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