Sonophoretic drug delivery system

• US 5,656,016 A
• Filed: 03/18/1996
• Issued: 08/12/1997
• Est. Priority Date: 03/18/1996
• Status: Expired due to Term

• Current Assignee: Hospira Incorporated (Pfizer Inc.)
• Original Assignee: Abbott Laboratories
• Inventors: Ogden, John E.
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): Tao, Ellen
• Application Number:
  US08/576,821
• Time in Patent Office: 512 Days
• Field of Search: 604/20, 604/22, 604/290, 128/660.01, 128/660.03, 601/2, 601/17
• US Class Current: 601/2
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Abstract

The present invention relates to devices and methods for enhancing the rate and efficacy of permeation of a drug into and through skin and into the circulatory system utilizing ultrasound.

Claims

1. A sonophoretic drug delivery system for delivering an agent or a drug to an animal comprising:

a generator constructed to generate an electrical signal at a predetermined frequency, a cable having a first end portion connected to said generator and having a second end portion, a transducer connected to said second end portion of said cable, said transducer constructed to convert said electrical signal into mechanical energy, said transducer being a wide-band transducer, a transmission line having a proximal end portion and a distal end portion, said proximal end portion connected to said transducer, said transmission line constructed to transmit mechanical energy therethrough, said distal end portion of said transmission line constructed to deliver mechanical energy to a drug delivery site, and a control system for adjusting said electrical signal.

2. A sonophoretic drug delivery system of claim 1 wherein said frequency is from about 20 KiloHertz to about 300 MegaHertz range.

3. A sonophoretic drug delivery system of claim 1 wherein said frequency is from about 1 MegaHertz to about 300 MegaHertz range.

4. A sonophoretic drug delivery system of claim 1 wherein said frequency is from about 10 MegaHertz to about 300 MegaHertz range.

5. A sonophoretic drug delivery system of claim 1 further comprising an amplifier constructed to boost said frequency of said electrical signal from said generator.

6. A method for delivering an agent transdermally comprising the steps of:

providing a drug delivery system, said system comprising a generator constructed to generate an electrical signal at a predetermined frequency, a cable having a first end portion connected to said generator and having a second end portion, a transducer connected to said second end portion of said cable, said transducer constructed to convert said electrical signal into mechanical energy, a transmission line having a proximal end portion and a distal end portion, said proximal end portion connected to said transducer, said transmission line constructed to transmit mechanical energy therethrough, said distal end portion of said transmission line constructed to deliver mechanical energy to a drug delivery site spaced from said transducer, and a control system for adjusting said electrical signal;

providing an agent for transdermal delivery;

placing said agent in contact with a drug delivery site on an animal;

placing said distal end portion of said transmission line in contact with said agent; and

activating said drug delivery system, whereby said agent is transdermally delivered at said drug delivery site.