DNA encoding macrophage migration inhibition factor from ocular lens

• US 5,656,737 A
• Filed: 02/28/1994
• Issued: 08/12/1997
• Est. Priority Date: 04/26/1991
• Status: Expired due to Term

• Current Assignee: United States Department Of Health And Human Services (Government of the United States of America), The US As Represented By The Department of Health and Human Service
• Original Assignee: United States Department Of Health And Human Services (Government of the United States of America)
• Inventors: Wistow, Graeme John
• Primary Examiner(s): Walsh, Stephen
• Assistant Examiner(s): Spector, Lorraine
• Application Number:
  US08/202,486
• Time in Patent Office: 1,261 Days
• Field of Search: 536/23.5, 530/350, 435/69.1
• US Class Current: 536/23.5
• CPC Class Codes: C07K 14/52 Cytokines; Lymphokines; Interferons
• CPC Class Codes: Y10S 530/829 Blood
• CPC Class Codes: Y10S 530/849 Eyes; vessels; umbilical cord

Abstract

Macrophage Migration Inhibition Factor (MIF) can be obtained from ocular lens of various birds and mammals. The amino acid sequences of lens MIF from mice, chickens and humans has been determined and the corresponding cDNA has been cloned.

Claims

1. A DNA sequence which codes for the amino acid sequence SEQ. ID. NO. 8.

2. The DNA sequence according to claim 1, which has nucleotide sequence SEQ. ID. NO. 3.

3. A DNA sequence which codes for the amino acid sequence SEQ. ID. NO. 10.

4. The DNA sequence according to claim 3, which has nucleotide sequence SEQ. ID. NO. 1.

5. A DNA sequence having nucleotide sequence SEQ. ID. NO. 1.

6. A DNA sequence having nucleotide sequence SEQ. ID. NO. 3.