Apparatus and method for noninvasive doppler ultrasound-guided real-time control of tissue damage in thermal therapy

• US 5,657,760 A
• Filed: 01/11/1996
• Issued: 08/19/1997
• Est. Priority Date: 05/03/1994
• Status: Expired due to Fees

• Current Assignee: Baylor College of Medicine (Baylor College)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Ying, Hao, Hartley, Craig J.
• Primary Examiner(s): JAWORSKI, FRANCIS J
• Application Number:
  US08/584,409
• Time in Patent Office: 586 Days
• Field of Search: 128/660.03, 128/661.07-661.1, 607/97, 601/2
• US Class Current: 600/439
• CPC Class Codes: A61B 18/00 Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body eye surgery A61F9/007; ear surgery A61F11/00
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 18/22 the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61B 8/488 involving Doppler signals
• CPC Class Codes: A61B 8/543 involving acquisition triggered by a physiological signal
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

A method and apparatus for noninvasive and real-time monitoring and feedback control of the extent and geometry of tissue damage induced by various thermal modalities (laser, electromagnetic wave, ultrasound and thermistor) in different thermal therapies (hyperthermia, thermal coagulation and ablation) is provided. Unlike the existing ultrasound configurations, which use non-Doppler ultrasound techniques, the single-beam configuration in this invention employs a multiple-range-gate pulsed Doppler technique. The configuration may be operated in A-mode, M-mode, or multi-dimensional image mode to monitor tissue thermal response in the tissue being treated at multiple tissue depths along the sound beam. By measuring changes in phase (i.e., motion) and amplitude (i.e., echogenicity) of the echoes returned from the tissue under treatment, the Doppler system can determine temporal and spatial profiles of tissue temperature and the extent and geometry of tissue thermal damage. The system can also differentiate tissue responses corresponding to coagulation of tissue (in hyperthermia or coagulation treatment) versus ablation of tissue. Further, the Doppler detection provides feedback signals using fuzzy logic technology to automatically and in real-time regulate thermal output of various thermal modalities so that optimal thermal treatment can be obtained. The control of thermal output is achieved by adjusting treatment parameters such as pulse rate, exposure time and output power in the case of lasers. The Doppler detection results can also be shown on a suitable display device to allow manual feedback control of a thermal modality by a human operator.

Claims

1. A method for ultrasonic Doppler monitoring of the extent and geometry of damage to a tissue resulting from treatment with a thermal modality, comprising the steps of:

providing an echo-Doppler transmitter/receiver coupled to a transducer;

treating a tissue with a thermal modality;

emitting ultrasonic waves from said transducer toward the region of a tissue receiving thermal treatment;

receiving echoes from the thermally treated tissue;

converting the echoes to electrical echo signals, said echo signals each containing a phase vector indicating motion and echogenicity in the tissue relative to the transducer at a plurality of tissue depths;

deriving x and y components of the phase vector of each echo signal as functions of range and time;

outputting pairs of in-phase and quadrature-phase (I and Q) Doppler signals; and

evaluating said I and Q Doppler signals to determine the extent and geometry of tissue damage resulting from said thermal treatment.

2. The method of claim 1, wherein said treating step comprises:

providing a laser coupled to an optical fiber;

directing a laser beam from said laser through said optical fiber into said tissue;

providing an ultrasonic transducer probe coupled to said echo-Doppler transmitter/receiver; and

angling said transducer probe relative to said optical fiber so that said laser beam emitted from said optical fiber and a sound beam emitted from said transducer probe will intersect below the surface of said tissue being treated with said laser.

3. The method of claim 1, wherein said treating step comprises:

providing a laser coupled to an optical fiber;

providing an ultrasonic transducer coupled to said echo-Doppler transmitter/receiver, wherein said transducer has a hollow core with said optical fiber disposed therein so that a laser beam projected through said optical fiber is substantially collinear with a sound beam emitted from said ultrasonic transducer.

4. The method of claim 1, wherein said evaluating step comprises:

eliminating background signals in I and Q Doppler signals to produce background-motion-free I and Q Doppler signals;

processing said background-motion-free I and Q Doppler signals to produce current dominant shift Doppler frequencies and accumulated dominant Doppler frequencies;

processing said current dominant shift Doppler frequencies and accumulated dominant Doppler frequencies to produce tissue temperature readings at multiple tissue depths and readings indicating the extent and geometry of tissue thermal damage at multiple tissue depths;

determining a tissue irreversible damage front from said readings indicating extent and geometry of tissue thermal damage; and

comparing a current tissue irreversible damage front to a user-desired tissue irreversible damage front to produce a difference signal and using the difference signal as well as the temperature of the current tissue irreversible damage front to produce a modulation signal for controlling the output of said thermal modality.

5. Apparatus for ultrasonic Doppler monitoring of the extent and geometry of damage due to thermal treatment of a living tissue, comprising:

a thermal modality for applying thermal treatment to a living tissue;

an echo-Doppler transmitter/receiver for emitting ultrasonic waves toward the region of said living tissue receiving thermal treatment, for receiving echoes from the treated tissue, and for converting the echoes to electrical signals, said electrical signals each containing a phase vector indicating motion and echogenicity in the tissue relative to the transducer at a plurality of tissue depths;

echo-signal processing means coupled to said echo-Doppler transmitter/receiver for deriving x and y components of the phase vector of each echo signal as functions of range and time and for outputting multiple pairs of I and Q Doppler signals; and

evaluating means coupled to said echo-signal processing means for determining the extent and geometry of tissue damage resulting from said thermal treatment.

6. The apparatus of claim 5, wherein said echo-signal processing means comprises:

a quadrature-phase detector coupled to said echo-Doppler transmitter/receiver for outputting x and y components of the phase vector;

a delayed-pulse generator coupled to said echo-Doppler transmitter/receiver for producing range-gate pulses;

a dual sample/hold circuit coupled to said quadrature-phase detector and said pulse generator for receiving x and y signals and range-gate pulses and for producing multiple pairs of I and Q Doppler signals; and

a lowpass filter coupled to receive said I and Q Doppler signals from said dual sample/hold circuit.

7. The apparatus of claim 5, further comprising:

a transducer probe coupled to said echo-Doppler transmitter/receiver, said transducer probe terminating in a probe tip.

8. The apparatus as recited claim 7, wherein said thermal modality comprises a laser coupled to an optical fiber.

9. The apparatus as recited in claim 8, wherein said transducer probe is angled relative to said optical fiber so that a laser beam emitted from said laser through said optical fiber and a sound beam emitted from said transducer will intersect below the surface of a tissue being treated with said laser.

10. The apparatus as recited in claim 8, wherein said transducer has a hollow core with said optical fiber disposed therein so that a laser beam projected through said optical fiber is substantially collinear with a sound beam emitted from said ultrasonic transducer.

11. The apparatus of claim 5, wherein said evaluating means further comprises:

means coupled to said Doppler detector for receiving I and Q Doppler signals and for eliminating background signals in said I and Q signals to produce background-motion-free I and Q Doppler signals;

means for processing said background-motion-free I and Q Doppler signals to produce current dominant shift Doppler frequencies and accumulated dominant Doppler frequencies;

means for processing said current dominant shift Doppler frequencies and accumulated dominant Doppler frequencies to produce tissue temperature readings at multiple tissue depths and readings indicating the extent and geometry of tissue thermal damage;

means for determining a tissue irreversible damage front from said readings indicating extent and geometry of tissue thermal damage; and

means for comparing a current tissue irreversible damage front to a user-desired tissue irreversible damage front to produce a difference signal and using the difference signal as well as the temperature of the current tissue irreversible damage front to produce a modulation signal for controlling the output of said thermal modality.