Filling material for soft tissue implant prostheses and implants made therewith

• US 5,658,329 A
• Filed: 02/14/1995
• Issued: 08/19/1997
• Est. Priority Date: 02/14/1995
• Status: Expired due to Term

• Current Assignee: Mentor Worldwide LLC (Johnson & Johnson)
• Original Assignee: Mentor Corporation (Johnson & Johnson)
• Inventors: Purkait, Bobby
• Primary Examiner(s): Prebilic, Paul B.
• Application Number:
  US08/389,751
• Time in Patent Office: 917 Days
• Field of Search: 623/7, 623/8, 623/11
• US Class Current: 623/23.72
• CPC Class Codes: A61F 2/0059 Cosmetic or alloplastic implants A61F2/10 - A61F2/16, A61F2/28 take precedence
• CPC Class Codes: A61F 2/12 Mammary prostheses and implants
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: C08L 1/28 Alkyl ethers
• CPC Class Codes: C08L 29/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: C08L 3/04 Starch derivatives , e.g. crosslinked derivatives
• CPC Class Codes: C08L 33/14 of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
• CPC Class Codes: C08L 33/26 Homopolymers or copolymers of acrylamide or methacrylamide
• CPC Class Codes: C08L 39/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C08L 5/04 Alginic acid; Derivatives thereof
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

A new soft tissue implant filling material is disclosed. The material may be polyvinylpyrollidone, polyvinyl alcohol, hydroxypropylmethyl cellulose, polyethylene oxide, hyaluronic acid, sodium or calcium alginate, hydrogel polyurethane, hydroxyethyl starch, polyglycolic acid, polyacrylamide, hydroxyethylmethacrylate (HEMA), and several naturally derived biopolymers including sodium kinate, seaweed, and agar.

Claims

1. An implantable soft tissue prosthesis comprising:

a hollow shell formed of a flexible elastomeric envelope, said shell having an inner volume and an exterior surface, said prosthesis being adapted to be surgically implanted and to retain a desired shape when filled with a filling material;

said filling material comprising a gel or viscous liquid containing polyacrylamide and derivatives of polyacrylamide having a solid content of such a formulation in the range of 2 to 20%, a viscosity in the range of 15,000 to 75,000 cps and a molecular weight in the range of 200,000 to 1.5 million;

said filling material having an osmolality in the range of 200 to 400 mOsm/kg, and a radiation penetration comparable with or better than that of 0.9% saline.