Drug releasing surgical implant or dressing material

• US 5,660,854 A
• Filed: 11/28/1994
• Issued: 08/26/1997
• Est. Priority Date: 11/28/1994
• Status: Expired due to Fees

• Current Assignee: Army Department of United States, The United States of America As Represented By The Secretary of Agriculture
• Original Assignee: Army Department of United States
• Inventors: Bodeker, Ben H., Kline, Mark D., Haynes, Duncan H
• Primary Examiner(s): Kishore, Gollamudi S.
• Application Number:
  US08/345,889
• Time in Patent Office: 1,002 Days
• Field of Search: 424/450, 424/443-447, 424/422-426, 606/228, 606/230, 606/231
• US Class Current: 424/450
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61L 2300/402 Anaestetics, analgesics, e.g. lidocaine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/412 Tissue-regenerating or healing or proliferative agents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/622 Microcapsules
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: Y10S 977/801 Drug
• CPC Class Codes: Y10S 977/906 Drug delivery
• CPC Class Codes: Y10S 977/915 Therapeutic or pharmaceutical composition
• CPC Class Codes: Y10T 442/2525 Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

Abstract

A surgical implant or external wound dressing which functions as both a hemostat and a device to safely and effectively deliver any of a number of pharmaceuticals to targeted tissue at a controlled rate is disclosed. The device generally comprises a carrier in the form of fibers, sutures, fabrics, cross-linked solid foams or bandages, a pharmaceutical in solid micoparticulate form releasably bound to the carrier fibers, and a lipid adjuvant which aids the binding of the microparticles to the fibers as well as their function in the body.

Claims

1. A drug delivering surgical implant, dressing, or suture comprising:

a carrier consisting essentially of fibers having diameters of between about 0.1 micrometers to about 100 micrometers, said fibers being coated with a multilamellar, amphiphatic membrane; and

,

a pharmaceutical releasably bound to said fibers, said pharmaceutical comprising solid microparticles of between about 20 nanometers to about 20 micrometers, said microparticles being coated with a multilamellar, amphiphatic membrane.

2. The drug delivering surgical implant, dressing, or suture of claim 1 wherein said carrier is a porous matrix with said fibers being covalently cross-linked.

3. The drug delivering surgical implant, dressing, or suture of claim 1 wherein said carrier comprises multiple strands of said fibers.

4. The drug delivering surgical implant, dressing, or suture of claim 1, wherein said pharmaceutical is selected from the group consisting of antiseptics, antibiotics, antiinflammatories, local anesthetics, tissue growth promoters, tissue destruction inhibitors, and combinations thereof.

5. The drug delivering surgical implant, dressing, or suture of claim 1, further comprising a preservative.

6. The drug delivering surgical implant, dressing, or suture of claim 5, wherein said preservative is taken from the group consisting of benzalkonium chloride, benzethonium chloride, propylparaben, butylparaben, chlorobutanol, benzyl alcohol, phenol, sodium benzoate, and EDTA.

7. The drug delivering surgical implant, dressing, or suture of claim 1 wherein said multilamellar, amphiphatic membrane is comprised of a substance selected from the group consisting of lecithin, phosphatidic acid, phosphatidyl serine, phosphatidyl inositol, caridolipin, phosphatidyl glycerol, phosphatidyl ethanolamine, sphinomyelin and monoglycerides.

8. The drug delivering surgical implant, dressing or suture of claim 1 wherein said coating substance is lecithin.