Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
First Claim
Patent Images
1. An oligonucleotide represented by SEQ ID NO:
- 10 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
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Abstract
Sequence-specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence-specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic or chemical synthesis. They are especially well suited as diagnostics, therapeutics, and research reagents in diseases mediated by Ha-ras or Ki-ras.
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Citations
18 Claims
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1. An oligonucleotide represented by SEQ ID NO:
- 10 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (3, 13)
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2. An oligonucleotide represented by SEQ ID NO:
- 10 wherein at least 75% of the nucleoside units are joined together by Rp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (4, 14)
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5. An oligonucleotide represented by SEQ ID NO:
- 11 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (7, 15)
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6. An oligonucleotide represented by SEQ ID NO:
- 11 wherein at least 75% of the nucleoside units are joined together by Rp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (8, 16)
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9. An oligonucleotide represented by SEQ ID NO:
- 12 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (11, 17)
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10. An oligonucleotide represented by SEQ ID NO:
- 12 wherein at least 75% of the nucleoside units are joined together by Rp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (12, 18)
Specification