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Combination of a cholesterol biosynthesis inhibitor and a .beta.-lactam cholesterol absorption inhibitor

  • US 5,661,145 A
  • Filed: 06/20/1995
  • Issued: 08/26/1997
  • Est. Priority Date: 12/23/1992
  • Status: Expired due to Term
First Claim
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1. A method of treating or preventing atherosclerosis or reducing plasma cholesterol levels comprising simultaneously or sequentially administering to a mammal in need of such treatment or prevention an effective amount of a cholesterol biosynthesis inhibitor selected from the group consisting of HMG CoA reductase inhibitors and a β

  • -lactam cholesterol absorption inhibitor represented by the structural formula ##STR9## or a pharmaceutically acceptable salt thereof, wherein D is B'"'"'--(CH2)q --, wherein B'"'"' is phenyl and q is 3 or 4;

    B'"'"'--O--(CH2)2 --, wherein B'"'"' is p-fluoro-phenyl or p-methoxyphenyl;

    3-phenyl-1-propenyl orB'"'"'--(CH2)--V--, wherein B'"'"' is phenyl and V is cyclopropylene;

    A is --(CH2)p --X--B wherein p is zero, X is a bond and B is ##STR10## R1, R2 and R3 are selected from the group consisting of H, lower alkoxy, alkoxyalkyl, alkoxyalkoxy, alkoxycarbonyl-alkoxy, lower alkyl lower alkanedioyl, allyloxy, phenoxy, OH, m-halogeno and --C(O)R12 ;

    R4 is (R7)n -substituted phenyl, wherein n is 1 and R7 is lower alkyl, lower alkoxy, halogeno, OH or --OCF3 ; and

    R12 is alkoxy.

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