Methods for treating neoplastic conditions using phenylacetic acid and derivatives thereof
First Claim
Patent Images
1. A method of treating a neoplastic condition in a subject comprising administering a therapeutic mount of a compound of the formula I:
- ##STR3## wherein R0 is aryl, phenoxy, substituted aryl or substituted phenoxy with the proviso that the substitution is not an amino substitution;
R1 and R2 are, independently, H, hydroxy, lower alkoxy, lower straight or branched chain alkyl or halogen;
R3 and R4 are, independently, H, lower alkoxy, lower or branched chain alkyl or halogen; and
n is an integer from 0 from 2;
a pharmaceutically-acceptable salt thereof or a mixture thereof.
0 Assignments
0 Petitions
Accused Products
Abstract
Compositions and methods of treating anemia, cancer, AIDS, or severe β-chain hemoglobinopathies by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof or derivatives thereof alone or in combination or in conjunction with other therapeutic agents. Pharmacologically-acceptable salts alone or in combinations and methods of preventing AIDS and malignant conditions, and inducing cell differentiation are also aspects of this invention.
43 Citations
30 Claims
-
1. A method of treating a neoplastic condition in a subject comprising administering a therapeutic mount of a compound of the formula I:
- ##STR3## wherein R0 is aryl, phenoxy, substituted aryl or substituted phenoxy with the proviso that the substitution is not an amino substitution;
R1 and R2 are, independently, H, hydroxy, lower alkoxy, lower straight or branched chain alkyl or halogen; R3 and R4 are, independently, H, lower alkoxy, lower or branched chain alkyl or halogen; and n is an integer from 0 from 2; a pharmaceutically-acceptable salt thereof or a mixture thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
- ##STR3## wherein R0 is aryl, phenoxy, substituted aryl or substituted phenoxy with the proviso that the substitution is not an amino substitution;
Specification