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Anti-scarring compositions comprising growth factor neutralizing antibodies

  • US 5,662,904 A
  • Filed: 09/27/1993
  • Issued: 09/02/1997
  • Est. Priority Date: 03/28/1991
  • Status: Expired due to Term
First Claim
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1. A method of inhibiting scar tissue formation during the healing of wounds, comprising the steps of administering to a host suffering from tissue wounding a growth factor neutralizing antibody specific against a growth factor selected from the group consisting of TGF-β

  • 1, TGF-β

    2 and PDGF, wherein the antibody neutralizes the stimulation of macrophage infiltration, fibroblast migration, extracellular matrix synthesis or deposition by fibroblasts, in the wound area before the granulation phase in a dosage effective to reduce activity of the growth factor.

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