Antimicrobial compositions useful for medical applications

• US 5,662,913 A
• Filed: 07/01/1994
• Issued: 09/02/1997
• Est. Priority Date: 04/10/1991
• Status: Expired due to Fees

• Current Assignee: Christopher C. Capelli
• Original Assignee: Christopher C. Capelli
• Inventors: Capelli, Christopher C.
• Primary Examiner(s): Hulina, Amy
• Application Number:
  US08/268,616
• Time in Patent Office: 1,159 Days
• Field of Search: 424/405, 424/409, 424/78.07, 424/78.08, 424/422, 424/430, 424/443, 424/618, 424/609, 424/669, 424/663, 424/723, 424/678, 424/679, 424/680, 424/670, 424/722, 523/105, 523/113, 523/122, 514/495, 604/265
• US Class Current: 424/405
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/16 Foams
• CPC Class Codes: A01N 25/22 containing ingredients stabilising the active ingredients
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A46D 1/00 Bristles; Selection of materials for bristles making artificial bristles D01D, D01F
• CPC Class Codes: A46D 1/006 Antimicrobial, disinfectant bristles, handle, bristle-carrier or packaging
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 47/60 the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• CPC Class Codes: A61K 47/6949 inclusion complexes, e.g. clathrates, cavitates or fullerenes
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/106 Halogens or compounds thereof, e.g. iodine, chlorite
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Antimicrobial metal-based compositions, which are photostable, non-staining, and which are easily absorbed into lipophilic matrices, contain silver cations, complexed by acyclic polyether polymers through the formation of a "host-guest relationship" where the acyclic polyether is the "host" and the silver cation is the "guest," wherein stabilization of this "host-guest relationship" is accomplished through the use of excess anions. The compositions are useful for topical treatment of infections caused by bacteria, fungus and viruses in humans and animals and for treating medical devices, foams and adhesives to impart infection-resistance.

Claims

1. In a foam composition comprised of a foam matrix which is dermatologically acceptable, moisture vapor-permeable, resistant to dissolution when exposed to water, and further comprising an antimicrobial composition,

the improvement wherein said antimicrobial composition is the antimicrobial composition consisting essentially of

(a) a stabilizing acyclic polyether polymer;

(b) silver ion; and

(c) a stabilizing anion, wherein said anion is selected from the group consisting of chloride, bromide, iodide and thiocyanate, wherein the ratio of equivalents of said anion to equivalents of said silver ion is greater than 4 to 1, when said anion is chloride;

is greater than 2.1 to 1, when said anion is bromide; and

is greater than 1.1 to 1, when said anion is iodide;

is greater than 3.5 to 1 when said anion is thiocyanate; and

wherein said antimicrobial composition has long-term photostability of greater than 72 hours in direct sunlight.

2. The foam composition of claim 1, wherein said acyclic polyether polymer is a polyurethane prepolymer.

3. A method of imparting antimicrobial protection to a foam object, comprising the steps of:

(a) providing an antimicrobial composition consisting essentially of

(i) a stabilizing acyclic polyether polymer;

(ii) silver ion; and

(iii) a stabilizing anion, wherein said anion is selected from the group consisting of chloride, bromide, iodide and thiocyanate, wherein the ratio of equivalents of said anion to equivalents of said silver ion is greater than 4 to 1, when said anion is chloride;

is greater than 2.1 to 1, when said anion is bromide; and

is greater than 1.1 to 1, when said anion is iodide;

is greater than 3.5 to 1, when said anion is thiocyanate; and

wherein said antimicrobial composition has long-term photostability of greater than 72 hours in direct sunlight;

(b) incorporating said antimicrobial composition during the production of a foam matrix; and

(c) drying said foam after said incorporation.

4. A method of imparting antimicrobial protection to a foam object, comprising the steps of:

(a) providing a (i) silver ion and

(ii) a stabilizing anion, wherein said anion is selected from the group consisting of chloride, bromide, iodide and thiocyanate, wherein the ratio of equivalents of said anion to equivalents of said silver ion is greater than 4 to 1, when said anion is chloride;

is greater than 2.1 to 1, when said anion is bromide; and

is greater than 1.1 to 1, when said anion is iodide;

is greater than 3.5 to 1 when said anion is thiocynate; and

(b) incorporating said antimicrobial composition during the production of a polyurethane foam matrix; and

(c) drying said foam after said incorporation.