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Reduction of liposome-induced adverse physiological reactions

  • US 5,662,930 A
  • Filed: 05/04/1995
  • Issued: 09/02/1997
  • Est. Priority Date: 05/21/1993
  • Status: Expired due to Term
First Claim
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1. A method of reducing a blood pressure decrease associated with the administration of a liposome to an animal which comprises incorporating a surface agent-modifying lipid comprising a phosphatidylethanolamine conjugated to a dicarboxylic acid into a liposome such that the surface agent-modifying lipid comprises at least about 2 mole percent of the lipid component of the liposome'"'"'s bilayer and then administering the liposome to the animal wherein an anti-inflammatory agent is administered to the animal prior to administration of the liposome composition and wherein the liposome has an average diameter of from at least about 200 nm to about 5000 nm.

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