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Prodrugs of phosphonates

DC CAFC
  • US 5,663,159 A
  • Filed: 10/11/1994
  • Issued: 09/02/1997
  • Est. Priority Date: 09/14/1990
  • Status: Expired due to Term
First Claim
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1. Antivirally active compounds or intermediates therefor of the formula I or V ##STR25## wherein B represents adenyl (A), guanyl (G), or 2,6-diaminopurinyl (DAP);

  • R1 and R2 are independently each OR4 R3 represents ##STR26## X represents hydrogen, methyl or hydroxymethyl;

    R4 represents a physiologically hydrolyzable group selected from the group consisting of CH2 OC(O)R5 and CH(R5)OC(O)R5 (R, S, or RS stereochemistry); and

    R5 represents C1 -C20 alkyl, aryl or aryl-alkyl which may be substituted or unsubstituted by hydroxy or halogen.

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