Cosmetic or dermatological composition containing at least one saponin of the ginsenoside type, and its applications, especially for treating the hair

• US 5,663,160 A
• Filed: 05/05/1995
• Issued: 09/02/1997
• Est. Priority Date: 09/17/1992
• Status: Expired due to Fees

• Current Assignee: Lvmh Recherche
• Original Assignee: Lvmh Recherche
• Inventors: Meybeck, Alain, Bonte, Frederic, Dumas, Marc
• Primary Examiner(s): Seidleck, James J.
• Assistant Examiner(s): Williamson, Michael A.
• Application Number:
  US08/387,824
• Time in Patent Office: 851 Days
• Field of Search: 424/70.1, 424/74, 424/195.1, 514/729, 514/880, 514/182
• US Class Current: 514/182
• CPC Class Codes: A61K 8/49 containing heterocyclic compounds
• CPC Class Codes: A61K 8/602 Glycosides, e.g. rutin
• CPC Class Codes: A61K 8/63 Steroids; Derivatives thereof
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/9794 Liliopsida [monocotyledons]
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/002 Aftershave preparations
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 5/006 Antidandruff preparations
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair
• CPC Class Codes: A61Q 7/00 Preparations for affecting hair growth

Abstract

The invention relates to a cosmetic or dermatological composition.

This composition contains, as active ingredient, a saponin of formula (I): ##STR1## in which: R₁ =-Glc(2-1)Glc,

R₂ =-Glc(6-1)Glc and

R₃ =H, the saponin being called G--Rb₁,

Glc denoting a β-D-glucopyranosyl group, or a plant extract in which it is present, and, if appropriate, cepharanthine or oxyacanthine, or a derivative thereof, or a plant extract in which it is present, such as an extract of Stephania cepharantha or Berberis.

This cosmetic or dermatological composition is intended in particular for promoting hair growth.

Claims

1. A topical composition for cosmetic and dermatological application comprising, as active ingredient, of between 0.001 and 2% by weight, based upon the total weight of the composition, of a plant extract containing between about 2% by weight and 60% by weight of at least the saponin denominated G--Rb₁ of formula (I):

##STR6## in which;

R₁ =-Glc(2-1)Glc, R₂ =-Glc(6-1)Glc and R₃ =H

wherein Glc denotes a β

-D-glucopyranosyl group.

2. The composition according to claim 1 characterized in that the plant extract also contains at least one other saponin of formula (I) given above in which:

R₁ =-Glc(2-1)Glc, R₂ =-Glc and R₃ =H, the saponin being called G-Rd, or

R₁ =-Glc, R₂ =-Glc(6-1)Glc and R₃ =H, the saponin being called Gy-XVII, or

R₁ =-Glc(2-1)Glc, R₂ =-Glc(6-1)Glc(6-1)Xyl and R₃ =H, the saponin being called N--R₄, or

R₁ =H, R₂ =-Glc and R₃ =--O-Glc(2-1)Rha, the saponin being called G--Re, or

R₁ =H, R₂ =-Glc and R₃ =--O-Glc, the saponin being called G-Rg₁, or

R₁ =H, R₂ =H and R₃ =--O-Glc, the saponin being called G--Rh₁, or

R₁ =H, R₂ =-Glc and R₃ =--O-Glc(2-1)Xyl, the saponin being called N--R₁, Glc, Xyl and Rha respectively being a β

-D-glucopyranosyl, β

-D-xylopyranosyl, and α

-L-rhamnopyranosyl group.

3. The composition according to claim 2 characterized in that the plant extract contains:

from 2 to 60% by weight of saponin G--Rb₁

from 2 to 60% by weight of saponin G-Rg₁

from 0 to 15% by weight of saponin G-Rd

from 0 to 15% by weight of saponin N--R₁

from 1 to 10% by weight of saponin G--Re based on the total weight of the extract.

4. The composition according to claim 2, characterized in that the plant extract contains:

from 10% to 60% by weight of saponin G--Rb₁

from 10% to 60% by weight of saponin G-Rg₁

from 0% to 15% by weight of saponin G-Rd

from 0% to 15% by weight of saponin N--R₁

from 1% to 10% by weight of saponin G--Re based on the total weight of the extract.

5. The composition according to claim 1 characterized in that the plant extract is an extract of Panax notoginseng or San-chi.

6. The composition according to claim 1 characterized in that the concentration of abovementioned plant extract is between 0.1 and 2% by weight, based on the total weight of the composition.

7. The composition according to claim 1 also comprising cepharanthine, oxyacanthine, a derivative thereof, or a plant extract in which said cepharanthine, oxyacanthine or a derivative thereof is present.

8. The composition according to claim 1 further comprising from 0.001 to 2% by weight of cepharanthine, oxyacanthine, a derivative thereof, or a plant extract in which said cepharanthine, oxyacanthine or a derivative thereof is present.

9. The composition according to claim 1 further comprising cepharanthine or oxyacanthine or a derivative thereof, at a concentration in the composition up to approximately equal to that of the total concentration of saponins therein.

10. The composition according to claim 1 also comprising an effective concentration of at least one other active substance selected from the group consisting of quinine and derivatives thereof, rubefacients, a papilla fibroblast culture supernatant, keratin-hydrolyzates, trace elements selected from the group consisting of zinc, selenium and copper, 5-α

-reductase inhibitors selected from the group consisting of progesterone and cyproterone acetate, azelaic acid and derivatives thereof, a 4-methyl-4-azasteroid, and an extract of Serona repens.

11. The composition according to claim 1 characterized in that it also contains from 0.01% to 1% by weight of hyaluronic acid.

12. A method for strengthening the protective functions of the skin and for retarding and treating wrinkles, which comprises applying, to the area to be treated, a composition according to claim 1 in an amount effective for achieving the indicated effect.

13. A method for retarding and treating wrinkles which comprises applying to the area to be treated a composition according to claim 1 in an amount effective for achieving the indicated effect.

14. A method for promoting hair growth, slowing down hair loss, treating androgenogenetic alopecia, and combating pruritus of the scalp, treating the skin, restoring, preserving and strengthening the protective function of the skin, or retarding and treating wrinkles, wherein said method comprises applying, to the area to be treated, a composition according to claim 1 in an amount effective for achieving said desired effect.

15. A cosmetic or dermatological composition for promoting hair growth, comprising, as active ingredient, an effective amount of an extract of Panax notoginseng or San-chi and cepharanthine or oxyacanthine, a derivative thereof, or a plant extract in which said cepharanthine, oxyacanthine or a derivative thereof, is present.

16. The composition according to claim 15 further comprising from 0.001 to 2% by weight of cepharanthine, oxyacanthine, a derivative thereof, or a plant extract in which said cepharanthine, oxyacanthine or derivative thereof is present.

17. The composition according to claim 15 further comprising cepharanthine, oxyacanthine or a derivative thereof, at a concentration in the composition approximately up to equal that of the total concentration of saponins therein.

18. The composition according to claim 15 also comprising an effective concentration of at least one other active substance selected from the group consisting of quinine and derivatives thereof, rubefacients, a papilla fibroblast culture supernatant, keratin hydrolyzates, trace elements selected from the group consisting of zinc, selenium and copper, 5-α

-reductase inhibitors selected from the group consisting of progesterone and cyproterone acetate, azelaic acid and derivative thereof, a 4-methyl-4-azasteroid and an extract of Serenoa repens.

19. The composition according to claim 15 characterized in that it also contains from 0.01% to 1% by weight of hyaluronic acid.

20. A method for promoting hair growth, slowing down hair loss, treating androgenogenetic alopecia, combating pruritus of the scalp, restoring, preserving and strengthening the protective function of the skin, or for retarding and treating wrinkles, which comprises applying, to the area to be treated, a composition according to claim 15 in an amount effective for achieving the indicated effect.

21. A topical composition for cosmetic and dermatological application consisting essentially, as active ingredient, of between 0.001 and 2% by weight, based upon the total weight of the composition, of a plant extract containing between about 2% by weight and 60% by weight of at least the saponin denominated G--Rb₁, of formula (I):

##STR7## in which;

R₁ =-Glc(2-1)Glc, R₂ =-Glc(6-1)Glc and R₃ =H

wherein Glc denotes a β

-D-glucopyranosyl group.

22. A composition consisting essentially of active ingredients of between 0.001 and 2% by weight, based upon the total weight of the composition, of a plant extract consisting essentially of:

from 2 to 60% by weight of saponin G--Rb₁,

from 2 to 60% by weight of saponin G-Rg₁,

from 0 to 15% by weight of saponin G-Rd,

from 0 to 15% by weight of saponin N--R₁, and

from 1 to 10% by weight of saponin G--Re based on the total weight of the extract.

23. A composition consisting essentially of active ingredients of between 0.001 and 2% by weight, based upon the total weight of the composition, of a plant extract consisting essentially of:

from 10% to 60% by weight of saponin G--Rb₁,

from 10% to 60% by weight of saponin G-Rg₁,

from 0 to 15% by weight of saponin G-Rd,

from 0 to 15% by weight of saponin N--R₁, and

from 1 to 10% by weight of saponin G--Re based on the total weight of the extract.

24. A topical composition for cosmetic and dermatological application consisting essentially, as active ingredient, of between 0.001 and 2% by weight, based on the total weight of the composition, of saponin denominated G--Rb₁, of formula (I):

##STR8## in which;

R₁ =-Glc(2-1)Glc, R₂ =-Glc(6-1)Glc and R₃ =H,

wherein Glc denotes a β

-D-glucopyranosyl group in an excipient appropriate for a topical cosmetic and dermatological application.

25. A topical composition for cosmetic and dermatological application consisting essentially of, as active ingredient, between 0.001 and 2% by weight, based on the total weight of the composition, of an extract of Panax notoginseng or San-chi in an excipient appropriate for a topical cosmetic and dermatological application.

26. A topical composition for cosmetic and dermatological application consisting essentially of, as active ingredient, from 0.001 and 2% by weight, based on the total weight of the composition, of a plant extract containing from 10% to 60% by weight of saponin G--Rb₁ and from 10% to 60% by weight of saponin G--Rg₁ based on the total weight of the extract, in an excipient which is appropriate for a topical cosmetic and dermatological application.