Tubular expanded polytetrafluoroethylene implantable prostheses

• US 5,665,114 A
• Filed: 08/12/1994
• Issued: 09/09/1997
• Est. Priority Date: 08/12/1994
• Status: Expired due to Term

• Current Assignee: Lifeshield Sciences LLC (Acacia Research Corporation)
• Original Assignee: Meadox Medicals, Inc. (Boston Scientific Corporation)
• Inventors: Weadock, Kevin, Lentz, David J., Zdrahala, Richard J.
• Primary Examiner(s): BRITTINGHAM, DEBRA
• Application Number:
  US08/289,790
• Time in Patent Office: 1,124 Days
• Field of Search: 623/1, 623/11, 623/12, 600/36, 606/153, 606/154, 606/158, 606/194, 606/195
• US Class Current: 623/1.34
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 27/22 Polypeptides or derivatives thereof , e.g. degradation products
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 27/18 Homopolymers or copolymers or tetrafluoroethene
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

An implantable prosthesis comprising an expanded polytetraethylene member having pores present in its wall structure wherein said pores contain a solid insoluble biocompatible, biodegradable material of natural origin. A process of preparing said prostheses is also disclosed.

Claims

1. An implantable member for use in repair or replacement with a body comprising an expanded polytetrafluoroethylene substrate having a wall structure including nodes and fibrils with pores present between said nodes and said fibrils, said pores filled with a fluid which solidifies and is crosslinked to form a solid precipitate of a insoluble biocompatible, biodegradable material of natural origin said material being insoluble at a pH of about 7.4.

2. An implantable member of claim 1 wherein said substrate comprises an implantable tubular prosthesis.

3. An implantable member of claim 1 wherein said substrate comprises an implantable surgical patch.

4. An implantable member of claim 1 wherein said substrate comprises an implantable mesh.

5. An implantable member of claim 1 wherein the insoluble biocompatible, biodegradable material substantially fills said pores to render the substrate blood-tight.

6. An implantable member of claim 1 wherein the biocompatible, biodegradable material includes extracellular matrix proteins.

7. An implantable member of claim 6 wherein said extracellular matrix protein is selected from the group consisting of collagen, including collagen I-V, gelatin, vitronectin, fibronectin, laminin, reconstituted basement membrane matrices and derivatives and mixtures thereof.

8. The prosthesis of claim 1 wherein the biocompatible, biodegradable material is cross-linked.

9. The prosthesis of claim 1 wherein the biocompatible, biodegradable material includes a pharmacological agent.

10. The prosthesis of claim 9 wherein said pharmacologically active agent is selected from the group consisting of antimicrobials, antivirals, antibiotics, growth factors, blood clotting modulators, antivirals and mixtures thereof.

11. The prosthesis of claim 1 wherein the polytetrafluoroethylene has been modified to enhance its hydrophilic character.

12. The prosthesis of claim 11 wherein the polytetrafluoroethylene has been subjected to glow discharge plasma deposition.