Method and compositions for lowering blood lipids
First Claim
1. A method of decreasing blood lipid levels comprising administering to a patient in need thereof an effective amount of shanzha to decrease the level of lipid in the blood.
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Abstract
It has been discovered that the Chinese fruit known as shanzha, and extracts and purified component derived therefrom, can be administered orally to animals to reduce levels of cholesterol in the blood. The mechanism of action is believed to include the "up-regulation" of LDL receptors on cell surfaces and inhibition of transcription factors for sterol responsive genes. Examples demonstrate the isolation of active components and extracts, potential mechanisms of action in animals and cell culture, and conditions promoting retention of activity during storage.
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Citations
14 Claims
- 1. A method of decreasing blood lipid levels comprising administering to a patient in need thereof an effective amount of shanzha to decrease the level of lipid in the blood.
- 11. A composition effective when administered to a patient to decrease blood lipids comprising a component present in an organic solvent/water extract of shanzha fruit which is active in hepatocyte cell culture to increase cellular uptake of lipids from the culture media.
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