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Preparation of peptide containing biodegradable microspheres by melt process

  • US 5,665,428 A
  • Filed: 10/25/1995
  • Issued: 09/09/1997
  • Est. Priority Date: 10/25/1995
  • Status: Expired due to Term
First Claim
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1. A process for preparing microspheres of an admixture of a biodegradable low melting point block copolymer and a water soluble and heat resistant peptide/protein drug, which comprises:

  • (a) preparing a molten mixture of an effective amount of peptide/protein drug microparticles and a biodegradable block copolymer at a temperature above the melting temperature of said block copolymer;

    (b) dispersing said molten mixture into a continuous fluid medium in such a manner as to form microdroplets of said molten mixture in said fluid medium;

    (c) lowering the temperature of said microdroplets in a cooling environment below the melting point of said block copolymer to form solid microspheres; and

    (d) separating said microspheres from said continuous fluid medium.

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