Method for rapid temporal control of molecular transport across tissue
First Claim
1. A method for transdermally treating an organism in response to an intrinsic condition, comprising the steps of:
- a) applying a medication to epidermis of the organism;
b) electroporating the epidermis at a first voltage pulse condition in response to said intrinsic condition to initiate delivery of the medication through the epidermis; and
c) electroporating said epidermis at a second voltage pulse condition, whereby the medication continues to pass through the epidermis at a rate sufficient to alter the intrinsic condition, thereby rapidly treating the organism.
1 Assignment
0 Petitions
Accused Products
Abstract
A method is disclosed for treating tissue in response to a stimulus generated by the tissue. In one embodiment, the method transdermally treats an organism in response to a stimulus. In this embodiment, the medication is applied to epidermis of the organism, and the epidermis is electroporated in response to a stimulus, whereby the medication passes through the epidermis at a rate sufficient to alter the stimulus, thereby transdermally treating the organism. In another embodiment, the method measures a blood component content of blood. A portion of epidermis is electroporated to cause an aqueous fluid to be directed through an electroporated epidermis to a surface of the epidermis. Thereafter, the blood component content of the aqueous fluid is measured for correlation with a known aqueous fluid blood component content associated with a known concentration of blood component in the blood. The blood component concentration of the blood can thereby be measured. In still another embodiment, the method includes directing a medication to the tissue which can alter the stimulus when the tissue is electroporated, and electroporating the tissue in response to a stimulus, whereby the medication passes through the tissue in an amount sufficient to alter the stimulus, thereby treating the organism.
137 Citations
25 Claims
-
1. A method for transdermally treating an organism in response to an intrinsic condition, comprising the steps of:
-
a) applying a medication to epidermis of the organism; b) electroporating the epidermis at a first voltage pulse condition in response to said intrinsic condition to initiate delivery of the medication through the epidermis; and c) electroporating said epidermis at a second voltage pulse condition, whereby the medication continues to pass through the epidermis at a rate sufficient to alter the intrinsic condition, thereby rapidly treating the organism. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
-
-
13. A method for treating an organism in response to an intrinsic condition susceptible to rapid alleviation, comprising the steps of:
-
a) directing a medication to tissue of the organism which can alter the intrinsic condition when the tissue is electroporated; b) electroporating the tissue at a first voltage pulse condition in response to the intrinsic condition to initiate delivery of the medication through the tissue; and c) electroporating said tissue at a second voltage pulse condition, whereby the medication passes through the tissue at a rate sufficient to rapidly alleviate the intrinsic condition. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
-
Specification