Method for producing ceramic implant materials, preferably ceramic implant materials including hydroxyl apatite

• US 5,667,796 A
• Filed: 06/05/1996
• Issued: 09/16/1997
• Est. Priority Date: 11/30/1993
• Status: Expired due to Term

• Current Assignee: botiss medical AG
• Original Assignee: Klaus Otten
• Inventors: Otten, Klaus
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): HOWARD, SHARON LEE
• Application Number:
  US08/658,526
• Time in Patent Office: 468 Days
• Field of Search: 424/422, 424/423, 424/426, 523/115, 530/353, 530/354, 530/355, 530/356, 623/18
• US Class Current: 424/422
• CPC Class Codes: A61F 2/3094 Designing or manufacturing processes
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/3683 subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
• CPC Class Codes: A61L 27/3691 characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation

Abstract

The present invention relates to a method for production of ceramic implant material, preferably ceramic implant material including hydroxyl apatite. According to the invention, for the production, the spongy parts of joints from animals, preferably grown-up cattle, are used, whereby the organic constituents of the spongy parts of the joints are removed by a quick burning, whereby one or more flushings of the remaining inorganic parts of the joints are effected without chemical additives and whereby said inorganic parts of the joints are sintered. The implant material can be used in connection with a mark inoculation method and in cell cultures.

Claims

1. Method for production of ceramic implant material, preferably ceramic implant material including hydroxyl apatite, characterized by using for the production the spongy parts of joints from animals, preferably grown-up cattle, removing the organic constituents of the spongy parts of the joints by a quick burning, effecting one or more flushings of the remaining inorganic parts of the joints without chemical additives and sintering of said inorganic parts of the joints.

2. A method for producing ceramic implant material comprising hydroxyapatite, the method consisting essentially of the steps of:

(a) obtaining a bone part from a joint of an animal;

(b) Cooling the bone part to a temperature of about 0°

C.;

(c) heating the cooled bone part in a furnace to remove a substantial amount of organic constituents from the bone part;

(d) washing the bone part with a non-acid bath after the heating of the bone part; and

(e) sintering the bone part after said washing step;

said heating in step (c) being performed with the infusion of excess oxygen into the furnace and without the maximum temperature exceeding the phase transformation temperature of the bone part.

3. The method of claim 2 wherein the bone part is an epiphysary or a metaphysary part.

4. The method of claim 3 wherein the heating in step (c) is performed in a short period of time and at a high temperature effective to remove organic constituents from the bone part without significantly raising the temperature at the center of the bone part.

5. The method of claim 4 in which step (b) is performed without pretreatment of the bone part between steps (a) and (b).

6. The method of claim 5 wherein the heating step of step (c) lasts from a few seconds to a maximum of thirty minutes.

7. The method of claim 6 including the further step (f) of washing the bone part following the sintering step (e) with a non-acid bath.

8. The method of claim 7 in which the pH of the ceramic implant material after the completion of step (f) is within the range of 6 to 12.

9. The method of claim 8 wherein said bath of step (d) comprises an aqueous fluid in an amount effective to dissolve solulizable components.

10. The method of claim 9 wherein the animal is a member of the cattle family.

11. The method of claim 10 wherein the animal is adult.

12. The method of claim 11 wherein the bone part is from the part of a hip joint, knee joint, shoulder joint or elbow joint of the animal.

13. The method of claim 12 wherein in step (c) the bone part is heated to above the ignition or inflammation temperature of the bone part.

14. A method for producing ceramic implant material comprising hydroxyapatite, the method consisting essentially of the steps of

(a) obtaining a bone part from a joint of an animal;

(b) cooling the bone part to a temperature of about -18°

C.;

(c) heating the cooled bone part in a furnace for about ten minutes at about 650°

C. to remove a substantial amount of organic constituents from the bone part;

(d) washing the bone part with a non-acid bath after the heating of the bone part;

(e) sintering the bone part after said washing step of step (d); and

(f) washing the sintered bone part with a non-acid bath obtain a desires pH in the range of about 6 to 12;

said heating in step (c) being performed with the infusion of excess oxygen into the furnace and without the maximum temperature exceeding the phase transformation temperature of the bone part.

15. The method of claim 14 wherein the bone part is an epiphysary or a metaphysary part.

16. The method of claim 15 wherein the heating in step (c) is performed in a short period of time and at a high temperature effective to remove organic constituents from the bone part without significantly raising the temperature at the center of the bone part.

17. The method of claim 16 in which step (b) is performed without pretreatment of the bone part between steps (a) and (b).

18. The method of claim 17 wherein the heating step of step (c) lasts from a few seconds to a maximum of thirty minutes.

19. The method of claim 18 wherein said bath of step (d) comprises an aqueous fluid in an amount effective to dissolve solulizable components.

20. The method of claim 19 wherein the animal is a member of the cattle family.

21. The method of claim 20 wherein the animal is adult.

22. The method of claim 21 wherein the bone part is from the soft part of a hip joint, knee joint, shoulder joint or elbow joint of the animal.

23. The method of claim 22 wherein in step (c) the bone part is heated to above the ignition or inflammation temperature of the part.

24. A method for producing ceramic implant material comprising hydroxyapatite, comprising the steps of

(a) obtaining a bone part from a joint of an animal;

(b) cooling said bone part to a cold temperature;

(c) heating said bone part in a furnace for a short time and at a high temperature effective to remove organic constituents from said bone part;

(d) washing said bone part with a fluid free of chemical

(e) sintering said bone part; and

(f) washing said bone part following the sintering of step (e) with a fluid comprising metallic salt solutions for protection against bacteria;

said heating in step (c) being performed With the infusion of excess oxygen into the furnace and without the maximum temperature exceeding the phase transformation temperature of the bone part.

25. The method of claim 24 wherein metals from said metallic salt solutions are bonded to said bone part.