Antacid composition

• US 5,667,802 A
• Filed: 05/15/1995
• Issued: 09/16/1997
• Est. Priority Date: 05/17/1994
• Status: Expired due to Fees

• Current Assignee: Georges Serge Grimberg
• Original Assignee: Georges Serge Grimberg
• Inventors: Grimberg, Georges Serge
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Benston, Jr., William E.
• Application Number:
  US08/441,294
• Time in Patent Office: 855 Days
• Field of Search: 424/464, 424/48, 424/440, 424/441, 426/5
• US Class Current: 424/464
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 33/08 Oxides; Hydroxides
• CPC Class Codes: A61K 33/10 Carbonates; Bicarbonates
• CPC Class Codes: A61K 33/42 Phosphorus; Compounds thereof
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Abstract

Antacids comprise a pharmaceutically acceptable gum coated with simethicone and a pharmaceutically acceptable antacid to provide prolonged antacid treatment to the stomach while preventing acid rebound. Compatible active ingredients can be included in the antacids, including analgesics, antibiotics, gold salts, and fluorine compounds.

Claims

1. A pharmaceutical antacid composition comprising:

(a) a pharmaceutically acceptable gum which forms a viscous suspension with water which suspension is viscous enough to adhere to the oesogastroduodenal lining;

said gum being coated with simethicone;

(b) an antacid salt.

2. The pharmaceutical antacid composition according to claim 1 wherein the gum is guar gum.

3. The pharmaceutical antacid composition according to claim 1 wherein the antacid salt is selected from pharmaceutically acceptable salts of magnesium and calcium.

4. The pharmaceutical antacid composition according to claim 1 further including a compatible therapeutically active substance.

5. The pharmaceutical antacid composition according to claim 1 wherein said compatible therapeutically active substance is selected from the group consisting of analgesics;

gold salts;

fluorine derivatives;

anticoagulants; and

antibiotics.

6. A method for treating excess gastrointestinal acidity comprising the step of administering a pharmaceutical antacid composition comprising a therapeutically effective amount of a pharmaceutical antacid composition according to claim 1.

7. The pharmaceutical antacid composition according to claim 1 wherein the ratio of simethicone is from about 10:

1 to about 1;

10 by weight of the composition.