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Morphine therapy

  • US 5,667,805 A
  • Filed: 10/04/1996
  • Issued: 09/16/1997
  • Est. Priority Date: 06/27/1994
  • Status: Expired due to Term
First Claim
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1. A dosage in the form of a tablet comprising:

  • a drug layer comprising 35 wt % morphine sulfate, 58.5 wt % polyethylene oxide possessing a 200,000 molecular weight, 6 wt % polyvinylpyrrolidone, 0.45 wt % magnesium stearate, and 0.05 wt % butylated hydroxytoluene which drug layer weighs 86 mg;

    a displacement-push layer comprising 93.67 wt % polyethylene oxide of 7,000,000 molecular weight, 5 wt % hydroxypropylmethylcellulose, 1 wt % ferric oxide, 0.25 wt % magnesium stearate, and 0.083 wt % butylated hydroxytoluene which displacement push layer weighs 55 mg;

    a semipermeable wall surrounding the layer; and

    a passageway on the semipermeable wall.

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