Morphine therapy
First Claim
Patent Images
1. A dosage in the form of a tablet comprising:
- a drug layer comprising 35 wt % morphine sulfate, 58.5 wt % polyethylene oxide possessing a 200,000 molecular weight, 6 wt % polyvinylpyrrolidone, 0.45 wt % magnesium stearate, and 0.05 wt % butylated hydroxytoluene which drug layer weighs 86 mg;
a displacement-push layer comprising 93.67 wt % polyethylene oxide of 7,000,000 molecular weight, 5 wt % hydroxypropylmethylcellulose, 1 wt % ferric oxide, 0.25 wt % magnesium stearate, and 0.083 wt % butylated hydroxytoluene which displacement push layer weighs 55 mg;
a semipermeable wall surrounding the layer; and
a passageway on the semipermeable wall.
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Abstract
A composition comprising morphine; and a dosage form comprising morphine are disclosed for morphine therapy. A method of using the composition and the dosage form are disclosed and indicated for morphine therapy.
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Citations
8 Claims
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1. A dosage in the form of a tablet comprising:
- a drug layer comprising 35 wt % morphine sulfate, 58.5 wt % polyethylene oxide possessing a 200,000 molecular weight, 6 wt % polyvinylpyrrolidone, 0.45 wt % magnesium stearate, and 0.05 wt % butylated hydroxytoluene which drug layer weighs 86 mg;
a displacement-push layer comprising 93.67 wt % polyethylene oxide of 7,000,000 molecular weight, 5 wt % hydroxypropylmethylcellulose, 1 wt % ferric oxide, 0.25 wt % magnesium stearate, and 0.083 wt % butylated hydroxytoluene which displacement push layer weighs 55 mg;
a semipermeable wall surrounding the layer; and
a passageway on the semipermeable wall. - View Dependent Claims (2, 3, 4)
- a drug layer comprising 35 wt % morphine sulfate, 58.5 wt % polyethylene oxide possessing a 200,000 molecular weight, 6 wt % polyvinylpyrrolidone, 0.45 wt % magnesium stearate, and 0.05 wt % butylated hydroxytoluene which drug layer weighs 86 mg;
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5. A dosage in the form of a tablet comprising:
- a drug composition comprising 35 wt % morphine sulfate, 58.5 wt % polyethylene oxide possessing a 200,000 molecular weight, 6 wt % polyvinylpyrrolidone, 0.45 wt % magnesium stearate and 0.05 wt % butylated hydroxytoluene;
a push composition comprising 63.675 wt % polyethylene oxide comprising a 7,000,000 molecular weight, 30 wt % sodium chloride, 5 wt % hydroxypropylcellulose, 1 wt % ferric oxide and 0.075 wt % butylated hydroxytoluene;
a semipermeable wall that surrounds the compositions; and
, a passageway in the wall. - View Dependent Claims (6, 7, 8)
- a drug composition comprising 35 wt % morphine sulfate, 58.5 wt % polyethylene oxide possessing a 200,000 molecular weight, 6 wt % polyvinylpyrrolidone, 0.45 wt % magnesium stearate and 0.05 wt % butylated hydroxytoluene;
Specification