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Composition for sustained release of human growth hormone

  • US 5,667,808 A
  • Filed: 06/07/1995
  • Issued: 09/16/1997
  • Est. Priority Date: 12/02/1992
  • Status: Expired due to Fees
First Claim
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1. A method for forming a metal cation-complexed human growth hormone, comprising the steps of:

  • a) forming a solution containing human growth hormone;

    b) dispersing a multivalent metal cation component with the human growth hormone solution under pH conditions suitable for complexing the multivalent metal cation with the human growth hormone, thereby forming a metal cation-complexed human growth hormone suspension wherein the molar ratio of metal cation component to hGH is between about 4;

    1 to about 100;

    1; and

    c) drying said suspension to form the metal cation-complexed human growth hormone.

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