Methods for joining tissue by applying radiofrequency energy to performed collagen films and sheets

• US 5,669,934 A
• Filed: 06/05/1995
• Issued: 09/23/1997
• Est. Priority Date: 02/13/1991
• Status: Expired due to Fees

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Fusion Medical Technologies Inc. (Baxter International Inc.)
• Inventors: Sawyer, Philip N.
• Primary Examiner(s): Bawa, Raj
• Application Number:
  US08/461,228
• Time in Patent Office: 841 Days
• Field of Search: 424/400, 606/7, 606/8, 606/10, 606/12, 606/17, 606/213, 606/214, 606/40, 606/3, 606/215, 128/898
• US Class Current: 606/213
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 18/12 by passing a current through the tissue to be heated, e.g. high-frequency current
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 27/24 Collagen

Abstract

A method for joining or restructuring tissue consists essentially of providing a preformed film or sheet of a solid filler material which fuses to tissue upon the application of energy. The material comprises collagen, gelatin, mixtures thereof, optionally combined with a plasticizer, and the film may be cut prior to placing over the tissue. Radiofrequency energy is then applied at between about 20 and 120 Watts to the filler material and the tissue after the filler material has been placed over the tissue for about 1 to 60 seconds so that about 20 to 1800 joules are delivered to the filler material and tissue.

Claims

1. A method of joining or restructuring tissue, said method consisting essentially of:

providing a preformed film or sheet of a solid filler material which fuses to tissue upon the application of energy, wherein the film or sheet comprises collagen, gelatin, or a mixture thereof;

placing the preformed film or sheet of filler material over the tissue to be joined or restructured; and

applying radiofrequency energy at between about 20 and 120 watts to the filler material and the tissue after said filler material has been placed over the tissue for about 1-60 seconds, so that about 20-1800 joules are delivered to the filler material and tissue.

2. A method as in claim 1, wherein the radiofrequency energy is applied from an inert gas beam radiofrequency device.

3. A method as in claim 2, wherein the radiofrequency inert gas beam device is operated at between about 35 and 80 watts for about 5 to 30 seconds, so that about 100 to 1200 joules are delivered to the filler material and tissue.

4. A method of joining or reconstructing biological tissue, said method consisting essentially of:

providing a preformed film or sheet of a solid filler material composed of collagen, collagen with a plasticizer, gelatin, gelatin with a plasticizer, or mixtures thereof;

cutting the preformed film or sheet to a desired size;

placing the cut film or sheet over the tissue to be joined or restructured; and

applying radiofrequency energy to the cut film or sheet of filler material at between about 20 and 120 watts for about 1-60 seconds, so that about 20-1800 joules are delivered to the filler material and tissue.

5. A method of joining or reconstructing biological tissue, said method consisting essentially of:

providing a preformed film or sheet of a solid filler material composed of collagen, collagen with a plasticizer, gelatin, or gelatin with a plasticizer;

placing the preformed film or sheet over the tissue to be joined or restructured; and

applying radiofrequency energy from an inert gas radio-frequency device at between about 20 and 120 watts to the film or sheet after said film or sheet has been placed over the tissue for about 1-60 seconds, so that about 20-1800 joules are delivered to the filler material and tissue.