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Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample

DC
  • US 5,670,325 A
  • Filed: 08/14/1996
  • Issued: 09/23/1997
  • Est. Priority Date: 08/14/1996
  • Status: Expired due to Term
First Claim
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1. A method for detecting the presence of a clonal subpopulation of transformed cells in a biological sample obtained from an organism, comprising the steps of:

  • a) determining from the biological sample a number X of a first wild-type polynucleotide characteristic of a genomic region of said organism that is not mutated in said subpopulation of transformed cells;

    b) determining from the biological sample a number Y of a second wild-type polynucleotide in a genomic region of said organism suspected of being mutated in said subpopulation of transformed cells; and

    c) determining whether a difference exists between number X and number Y,the presence of a statistically-significant difference being indicative of a clonal subpopulation of transformed cells in said biological sample.

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