Medical instruments that exhibit surface lubricity when wetted

• US 5,670,558 A
• Filed: 07/06/1995
• Issued: 09/23/1997
• Est. Priority Date: 07/07/1994
• Status: Expired due to Term

• Current Assignee: Terumo Kabushiki Kaisha
• Original Assignee: Terumo Kabushiki Kaisha
• Inventors: Ishii, Naoki, Onishi, Makoto, Shimura, Kenichi
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Shelborne, Kathryne E.
• Application Number:
  US08/498,796
• Time in Patent Office: 810 Days
• Field of Search: 523/112, 523/105, 523/113, 523/122, 604/265
• US Class Current: 523/112
• CPC Class Codes: A61L 2400/10 Materials for lubricating medical devices
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61L 29/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 33/0011 Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
• CPC Class Codes: A61L 33/0029 using an intermediate layer of polymer
• CPC Class Codes: A61M 2025/0046 Coatings for improving slidability
• CPC Class Codes: A61M 2025/1088 having special surface characteristics depending on material properties or added substances, e.g. for reducing friction
• CPC Class Codes: A61M 25/1027 Making of balloon catheters

Abstract

This invention provides a medical instrument having on a surface a layer (surface lubricating layer) that forms a hydrogel when wetted and that is composed of an insolubilized water-soluble or water-swellable polymer having a reactive functional group in the molecule. The surface having outstanding surface lubricity and, optionally, the ability to prevent the formation of thrombi.

Claims

1. A medical instrument exhibiting surface lubricity when wetted, comprising a surface coated with a surface lubricating layer, said surface lubricating layer comprising a block or graft copolymer having a hydrophilic domain and a reactive domain, said reactive domain having a reactive functional group selected from the group consisting of epoxy and isocyanate, and wherein said functional group is cross-linked with another functional group.

2. A medical instrument according to claim 1, wherein said surface lubricating layer further comprises a polymer having a functional group selected from the group consisting of a carboxyl group, an amino group, a hydroxyl group, and a maleic anhydride group.

4. A medical instrument according to claim 1, wherein said surface lubricating layer further comprises an antithrombotic agent.

5. A medical instrument according to claim 1, wherein the molar ratio of said hydrophilic domains to said reactive domains is 1:

50.

6. A medical instrument according to claim 1, wherein said surface lubricating layer is formed by coating said block or graft copolymer on the surface of the medical instrument;

and heating said coating to at least 40°

C.

3. A medical instrument exhibiting surface lubricity when wetted, comprising a matrix material surfaced with a surface lubricating layer comprising a block or graft copolymer having a hydrophilic domain and a reactive domain, said reactive domain having a reactive functional group selected from the group consisting of an epoxy group and an isocyanate group, wherein said surface lubricating layer is formed by dipping the matrix material in a solution of said block or graft copolymer;

and wherein said functional group is cross-linked with another functional group to form an interpenetrating network structure between the matrix material and the copolymer.

7. A medical instrument according to claim 3, wherein the swelled ratio of the matrix surface is within the range of 1 to 100% as defined by equation (1):

##EQU5## wherein W_o =the weight of the matrix material before dipping the matrix material into the solution; and

Δ

W=the increased weight of the matrix material after dipping into the solution.