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Molecular detection apparatus and method using optical waveguide detection

  • US 5,671,303 A
  • Filed: 04/17/1996
  • Issued: 09/23/1997
  • Est. Priority Date: 04/17/1996
  • Status: Expired due to Fees
First Claim
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1. A method of molecular detection, the method comprising the steps of:

  • providing an optical waveguide having a surface proximate to a binding site;

    applying an incident light beam to the binding site along an axis transverse to the surface of the optical waveguide, the incident light beam impinging an optical indicator bound at the binding site to form secondary light which is coupled into the optical waveguide;

    detecting the secondary light in the optical waveguide; and

    reflecting a portion of the incident light beam which passes through the binding site back toward the binding site to enhance an illumination thereof.

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