Covered expanding mesh stent

• US 5,674,241 A
• Filed: 07/15/1996
• Issued: 10/07/1997
• Est. Priority Date: 02/22/1995
• Status: Expired due to Term

• Current Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Original Assignee: Menlo Care, Inc. (Johnson & Johnson)
• Inventors: Van Bladel, Kevin H., Bley, Robert S., Thomas, Joseph R.
• Primary Examiner(s): Tucker, Guy V.
• Assistant Examiner(s): Lewis, William W.
• Application Number:
  US08/680,717
• Time in Patent Office: 449 Days
• Field of Search: 606/1, 606/108, 606/192-195, 606/198, 606/200, 623/1, 623/11, 623/12
• US Class Current: 623/1.2
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 31/10 Macromolecular materials

Abstract

The present invention is a medical device such as a stent in the form of an expandable mesh with an expandable polymer layer thereon. The mesh is metal or plastic. The polymer may be any of a variety of expandable polymers, which either expand upon hydration, or expand without significant resistance. The invention may be used, for example, as an expandable biliary, vascular, endotracheal, esophageal, or prostatic device.

Claims

1. A stent for insertion into the interior of a body comprising:

an expandable stent body, said expandable stent body having a first configuration having a first diameter and a second configuration having a second diameter wherein said first diameter is less than said second diameter; and

,

an expandable polymer layer coupled with said expandable stent body, said expandable polymer layer being hydrophilic, said expandable polymer layer expanding upon hydration to form an expanded polymer layer, said expanded polymer layer coupled with said expandable stent body as one of an internal liner-like layer inside said expandable stent body an external sheath-like layer outside said expandable stent body, an interstitial layer disposed within interstices in said expandable stent body, and any combination thereof.

2. The stent of claim 1 wherein said expandable stent body is self-expanding.

3. The stent of claim 2 wherein said expandable polymer layer holds said expandable stent body in said first configuration prior to hydration of said expandable polymer layer, and allows said expandable stent body to expand to said second configuration upon hydration of said expandable polymer layer.

4. The stent of claim 1 wherein said expandable stent body comprises a material selected from the group consisting of stainless steel, tantalum, gold, titanium, nitinol, and plastic.

5. The stent of claim 1 wherein said expandable stent body has a configuration selected from the group consisting of coiled spring, braided filament, perforated tube, slit tube, and zig-zag.

6. The stent of claim 1 wherein said expandable polymer layer comprises a material selected from the group consisting of:

a blend of a hydrophilic polymer and a non-hydrophilic polymer, hydrolyzed polyacrylonitrile, hydrophilic polyether polyurethane, polyurethane diacrylate, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene oxide and poly (hydroxyethyl methacrylate).

7. The stent of claim 1 said expandable polymer layer has an additive contained therein.

8. The stent of claim 7 wherein said additive is selected from the group consisting of antibacterial, anti-microbial, anti-calcification, anti-encrustation, growth hormones, anti-cancer-related drugs, medicaments, anti-thrombogenic agents, and anti-restenosis agents.

9. The stent of claim 1 wherein said expandable stent body has a first expansion ratio and said expandable polymer layer has a second expansion ratio, wherein said first and said second expansion ratio are approximately equal.

10. The stent of claim 1 wherein said stent has an enhanced expansion force compared with said expandable stent body alone and said expandable polymer layer alone.

11. The stent of claim 1 wherein said stent has an enhanced crush resistance compared with said expandable stent body alone and said expandable polymer layer alone.

12. The stent of claim 1 wherein said expandable polymer layer inhibits tissue in-growth through walls of said stent.

13. The stent of claim 1 wherein said expandable polymer layer inhibits liquid flow through walls of said stent.

14. A stent for insertion into the interior of a body comprising:

an expandable stent body, said expandable stent body having a first configuration having a first diameter and a second configuration having a second diameter wherein said first diameter is less than said second diameter; and

,

an expandable polymer layer coupled with said expandable stent body, said expandable polymer layer being hydrophilic, said expandable polymer layer expanding upon hydration, wherein said expandable polymer layer has a coating thereon, said coating delaying hydration of said expandable polymer layer for a predetermined time.

15. A stent for insertion into the interior of a body comprising:

an expandable stent body, said expandable stent body having a first configuration having a first diameter and a second configuration having a second diameter wherein said first diameter is less than said second diameter, said expandable stent body having a tendency to expand from said first configuration to said second configuration; and

,

an expandable polymer layer coupled with said expandable stent body, said expandable polymer layer being hydrophilic, said expandable polymer layer expanding upon hydration to form an expanded polymer layer, said expandable polymer layer holding said expandable stent body in said first configuration prior to expansion, said expandable polymer layer remaining coupled to said expandable stent body after expansion.

16. The stent of claim 15 wherein said expandable stent body is self-expanding.

17. The stent of claim 16 wherein said expandable polymer layer holds said expandable stent body in said first configuration prior to hydration of said expandable polymer layer, and allows said expandable stent body to expand to said second configuration upon hydration of said expandable polymer.

18. The stent of claim 15 wherein said expandable stent body comprises a material selected from the group consisting of stainless steel, tantalum, gold, titanium, nitinol, and plastic.

19. The stent of claim 15 wherein said expandable stent body has a configuration selected from the group consisting of coiled spring, braided filament, perforated tube, slit tube, and zig-zag.

20. The stent of claim 15 wherein said expandable polymer layer comprises a material selected from the group consisting of:

a blend of a hydrophilic polymer and a non-hydrophilic polymer, hydrolyzed polyacrylonitrile, hydrophilic polyether polyurethane, polyurethane diacrylate, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene oxide and poly (hydroxyethyl methacrylate).

21. The stent of claim 15 wherein said expandable polymer layer is disposed on one of the inside of said expandable stent body, the outside of said expandable stent body, the interstices of said expandable stent body, and any combination thereof.

22. The stent of claim 21 wherein said expandable stent body has a first expansion ratio and said expandable polymer layer has a second expansion ratio, wherein said first and said second expansion ratio are approximately equal.

23. The stent of claim 15 said expandable polymer layer has an additive contained therein.

24. The stent of claim 23 wherein said additive is selected from the group consisting of antibacterial, anti-microbial, anti-calcification, anti-encrustation, growth hormones, anti-cancer-related drugs, medicaments, anti-thrombogenic agents, and anti-restenosis agents.

25. The stent of claim 15 wherein said expandable polymer layer has a coating thereon, said coating delaying hydration of said expandable polymer layer for a predetermined time.

26. The stent of claim 15 wherein said stent has an enhanced expansion force compared with said expandable stent body alone and said expandable polymer layer alone.

27. The stent of claim 15 wherein said stent has an enhanced crush resistance compared with said expandable stent body alone and said expandable polymer layer alone.

28. The stent of claim 15 wherein said expandable polymer layer inhibits tissue in-growth through walls of said stent.

29. The stent of claim 15 wherein said expandable polymer layer inhibits liquid flow through walls of said stent.