Bioabsorbable medical implants

• US 5,674,286 A
• Filed: 07/15/1992
• Issued: 10/07/1997
• Est. Priority Date: 02/12/1991
• Status: Expired due to Term

• Current Assignee: United States Surgical Corporation (Medtronic Plc)
• Original Assignee: United States Surgical Corporation (Medtronic Plc)
• Inventors: D'Alessio, Keith, Kennedy, John, Muth, Ross R., Kaplan, Donald S.
• Primary Examiner(s): Isabella, David J.
• Application Number:
  US07/914,437
• Time in Patent Office: 1,910 Days
• Field of Search: 623/11, 623/16, 623/66, 623/13, 623/12, 606/60, 606/69, 606/77, 606/70, 606/76
• US Class Current: 424/423
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30965 Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/129 containing macromolecular fillers
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

A completely bioabsorbable reinforced composite material for use in medical implants and a method for making same. The composite material comprises a hybrid yarn of intimately co-mingled reinforcement fibers of a crystalline polymer and matrix fibers of a polymer having a glass transition temperature below the melting point of the crystalline polymer. The hybrid yarn is heated under pressure to a processing temperature between the glass transition temperature of the matrix fibers and the melting point of the crystalline polymer to form a continuous matrix with reinforcing fibers of crystalline polymer. The composite material may be formed by a two step consolidation process.

Claims

1. A bioabsorbable composite surgical implant comprising a hybrid yarn of plied reinforcing and matrix fibers, the reinforcing fibers being made of a bioabsorbable crystalline polymer characterized by a melting point and the matrix fibers being made of a bioabsorbable polymer characterized by a glass transition temperature below the melting point of the crystalline polymer, said hybrid yarn being heated under pressure to a processing temperature above the glass transition temperature of the matrix fibers and below the melting point of the crystalline polymer.

2. The bioabsorbable composite material of claim 1, wherein reinforcing fiber is spun from a polymer selected from the group consisting of polylactic acid, polyglycolic acid, polydioxanone, polytrimethylene carbonate, poly(ethylene carbonate), poly(iminocarbonates), polycaprolactone, polyhydroxybutyrate, polyalkylene oxalates, polyalkylene succinates, poly(maleic acid), poly(1,3-propylene malonate), poly(ethylene terephthalate), poly(amino acids), and copolymers thereof.

3. The bioabsorbable composite material of claim 1, wherein said bioabsorbable polymers of said matrix fibers are substantially amorphous.

4. The bioabsorbable composite material of claim 1, wherein the bioabsorbable polymer of said matrix fibers contain a bioabsorbable component having a melting point below said processing temperature.

5. The bioabsorbable composite material of claim 4, wherein said component is selected from the group consisting of polycaprolactone, polytrimethylene carbonate, polydioxanone, polyorthoesters, copolymers of caprolactone and at least one comonomer selected from the group consisting of and lactic acid and glycolic acid, copolymers of trimethylene carbonate and at least one comonomer selected from the group consisting of lactic acid and glycolic acid, and copolymers of dioxanone and at least one comonomer selected from the group consisting of lactic acid and glycolic acid.

6. The bioabsorbable composite material of claim 4, wherein said hybrid yarn is treated to remove at least one compound selected from the group consisting of monomers and impurities before said hybrid yarn is heated to the processing temperature.

7. The bioabsorbable composite material of claim 6, wherein said treatment to remove at least one compound selected from the group consisting of monomers and impurities comprises heating said hybrid yarn to a temperature from about 75°

C. to 120°

C. under at least a partial vacuum for a period of time sufficient to remove a substantial amount of the compounds.

8. A bioabsorbable composite surgical implant comprising a hybrid yarn of plied reinforcing and matrix fibers, the reinforcing fibers being made of a bioabsorbable crystalline polymer characterized by a melting point and the matrix fibers being made of a blend of bioabsorbable polymers characterized by a glass transition temperature below the melting point of the crystalline polymer, said hybrid yarn being heated under pressure to a processing temperature above the glass transition temperature of the matrix fibers and below the melting point of the crystalline polymer.