Dosage form comprising oxybutynin
DCFirst Claim
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1. A therapeutic composition comprising:
- 1 ng to 450 mg of oxybutynin, 40 mg to 250 mg of polyalkylene oxide, 1 mg to 25 mg of hydroxypropylalkylcellulose, and 0.01 mg to 5 mg of a lubricant.
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Abstract
A composition comprising oxybutynin and a device comprising oxybutynin are disclosed for oxybutynin therapy.
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Citations
7 Claims
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1. A therapeutic composition comprising:
- 1 ng to 450 mg of oxybutynin, 40 mg to 250 mg of polyalkylene oxide, 1 mg to 25 mg of hydroxypropylalkylcellulose, and 0.01 mg to 5 mg of a lubricant.
- View Dependent Claims (2)
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3. A bilayered tablet comprising a therapeutic layer comprising 1 ng to 450 mg of oxybutynin, 40 mg to 450 mg of polyalkylene oxide, 1 mg to 25 mg of hydroxypropylalkylcellulose and 0.01 mg to 5 mg of a lubricant;
- in contact with a hydrogel layer comprising 40 mg to 250 mg of polyalkylene oxide, 10 mg to 50 mg of an osmagent, 0.1 mg to 20 mg of hydroxypropylalkylcellulose, 0.0 ng to 1.5 mg of an antioxidant, and 0.2 mg to 7 mg of a lubricant.
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4. A bilayered tablet comprising a therapeutic layer comprising a therapeutic layer comprising 1 ng to 450 mg of oxybutynin, 40 mg to 250 mg of polyalkylene oxide, 1 mg to 25 mg of hydroxypropylalkylcellulose, and 0.01 mg to 5 mg of a lubricant;
- said layer in contact with a push layer comprising 40 mg to 250 mg of an alkali carboxymethylcellulose, 10 mg to 50 mg of an osmagent, 0.1 mg to 20 mg of hydroxypropylalkylcellulose, 0.1 mg to 30 mg of hydroxyalkylcellulose, 0.0 ng to 1.5 mg of an antioxidant, and 0.2 mg to 7 mg of a lubricant.
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5. A delivery device for administering oxybutynin to a patient in need of oxybutynin, wherein the delivery device comprises:
- a layer comprising 1 ng to 450 mg of oxybutynin, 40 mg to 250 mg of polyalkylene oxide, 1 mg to 25 mg of hydroxypropylalkylcellulose, and 1 mg to 50 mg of an osmagent; and
contacting layer comprising 40 mg to 250 mg of an osmopolymer and 10 mg to 50 mg of an osmagent;
a semipermeable wall that surrounds the layers, which semipermeable wall is permeable to the passage of fluid, and impermeable to the passage of oxybutynin, and an exit through the semipermeable wall for administering the oxybutynin to the patient at a controlled rate over time.
- a layer comprising 1 ng to 450 mg of oxybutynin, 40 mg to 250 mg of polyalkylene oxide, 1 mg to 25 mg of hydroxypropylalkylcellulose, and 1 mg to 50 mg of an osmagent; and
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6. A delivery device for administering oxybutynin to a patient in need of oxybutynin, wherein the delivery device comprises:
- a drug layer comprising 1 ng to 450 mg of oxybutynin, 40 mg to 250 mg of polyalkylene oxide, 1 mg to 25 mg of hydroxypropylalkylcellulose, 1 mg to 50 mg of an osmagent; and
a contacting displacement layer comprising 40 mg to 250 mg of carboxymethylcellulose and 10 mg to 50 mg of an osmagent;
a semipermeable wall that surrounds the layers, which semipermeable wall is permeable to the passage of fluid, and impermeable to the passage of oxybutynin, and an exit through the semipermeable wall for administering the oxybutynin to the patient at a controlled rate over time.
- a drug layer comprising 1 ng to 450 mg of oxybutynin, 40 mg to 250 mg of polyalkylene oxide, 1 mg to 25 mg of hydroxypropylalkylcellulose, 1 mg to 50 mg of an osmagent; and
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7. A delivery device for administering oxybutynin to a patient in need of oxybutynin, wherein the delivery device comprises:
- a drug layer comprising 1 ng to 450 mg of oxybutynin, 40 mg to 250 mg of polyalkylene oxide, 1 mg to 25 mg of a hydroxypropylalkylcellulose, 1 mg to 50 mg of an osmagent; and
a contracting displacement layer comprising 40 mg to 250 mg of polyalkylene oxide, and 10 mg to 50 mg of an osmagent;
a semipermeable wall that surrounds the layer, which semipermeable wall is permeable to the passage of fluid, and impermeable to the passage of oxybutynin, and an exit through the semipermeable wall for administering the oxybutynin to the patient at a controlled rate over time.
- a drug layer comprising 1 ng to 450 mg of oxybutynin, 40 mg to 250 mg of polyalkylene oxide, 1 mg to 25 mg of a hydroxypropylalkylcellulose, 1 mg to 50 mg of an osmagent; and
Specification