Stilbene compounds and pharmaceutical compositions containing them

• US 5,674,906 A
• Filed: 03/07/1996
• Issued: 10/07/1997
• Est. Priority Date: 03/07/1995
• Status: Expired due to Term

• Current Assignee: Ajinomoto Co., Inc.
• Original Assignee: Ajinomoto Co., Inc.
• Inventors: Nakagawa, Ryusuke, Tsuji, Takashi, Hatanaka, Toshihiro, Nihei, Yukio, Ohsumi, Koji, Ohishi, Kazuo
• Primary Examiner(s): O SULLIVAN, PETER G
• Application Number:
  US08/612,416
• Time in Patent Office: 579 Days
• Field of Search: 514/419, 514/423, 514/521, 514/563, 514/620, 514/626, 548/491, 548/537, 558/402, 562/450, 564/194
• US Class Current: 514/626
• CPC Class Codes: C07C 237/04 the carbon skeleton being acyclic and saturated
• CPC Class Codes: C07C 255/44 at least one of the singly-bound nitrogen atoms being acylated
• CPC Class Codes: C07D 207/16 Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

Stilbene compounds of the following formula (I) or their pharmaceutically acceptable salts are effective as carcinostatics and of low toxicity: ##STR1## wherein X represents a hydrogen atom or a nitrile group, and Y represents an amino acid acyl group.

Claims

1. A stilbene compound represented by formula (I) ##STR19## wherein X represents a hydrogen atom or a nitrile group, and Y represents an amino acid acyl group.

2. The stilbene compound of claim 1, wherein X is a hydrogen atom.

3. The stilbene compound of claim 1, wherein X is a nitrile group.

4. The stilbene compound of claim 1 or 2, wherein Y is L-α

-amino acid acyl group.

5. The stilbene compound of claim 4, wherein Y is a threonine or serine residue.

6. A pharmaceutical composition comprising a carcinostatically effective amount of a stilbene compound or a pharmaceutically acceptable salt thereof of claim 1 and a pharmaceutically acceptable excipient, diluent or carrier.

7. A method for treating cancer in a subject comprising administering to said subject in need of such treatment a carcinostatically effective amount of a compound of claim 1.