Excitatory amino acid receptor antagonists
First Claim
Patent Images
1. A process for the preparation of a compound of the formula ##STR87## wherein:
- R9 is acyl or alkoxycarbonyl; and
R10 is hydrogen, C1 -C6 alkyl, or aryl;
which comprises the steps of;
(1) stereoselectively reducing a compound of formula ##STR88## wherein R9 and R10 are as defined previously, with a hydrogenation catalyst and hydrogen wherein the hydrogenation catalyst is rhodium on carbon, to produce a compound of the formula ##STR89## wherein R9 and R10 are as defined previously; and
(2) oxidizing said formula VII compound.
0 Assignments
0 Petitions
Accused Products
Abstract
This invention provides novel decahydroisoquinoline compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides synthetic methods for preparing decahydroisoquinolines, as well as, novel intermediates in the synthesis thereof.
9 Citations
9 Claims
-
1. A process for the preparation of a compound of the formula ##STR87## wherein:
- R9 is acyl or alkoxycarbonyl; and
R10 is hydrogen, C1 -C6 alkyl, or aryl; which comprises the steps of; (1) stereoselectively reducing a compound of formula ##STR88## wherein R9 and R10 are as defined previously, with a hydrogenation catalyst and hydrogen wherein the hydrogenation catalyst is rhodium on carbon, to produce a compound of the formula ##STR89## wherein R9 and R10 are as defined previously; and
(2) oxidizing said formula VII compound. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- R9 is acyl or alkoxycarbonyl; and
Specification