Apparatus for administering medical therapy using detrended fluctuation analysis of physiological activity

• US 5,676,690 A
• Filed: 12/05/1996
• Issued: 10/14/1997
• Est. Priority Date: 12/05/1996
• Status: Expired due to Term

• Current Assignee: Pacesetter AB
• Original Assignee: Pacesetter AB
• Inventors: Noren, Kjell
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US08/761,755
• Time in Patent Office: 313 Days
• Field of Search: 607/2, 607/4, 607/5, 607/9, 607/17
• US Class Current: 607/9
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

An implantable medical apparatus includes a therapy unit which produces a medical therapy regimen which is administered by the implantable medical apparatus to a subject. The implantable medical apparatus obtains an electrical signal representing physiological activity of the subject and performs detrended fluctuation analysis on the electrical signal so as to obtain a self-similarity parameter for the electrical signal. Deviations of the self-similarity parameter from a nominal value indicate the severity of the pathology of the subject which the implanted medical apparatus is intended to treat. The self-similarity parameter can be made extracorporeally available for use by a physician to evaluate the effectiveness of a treatment program currently in place, and/or can be supplied to a control unit of the implantable medical apparatus for use in automatically adjusting the therapy regimen administered by the implantable medical apparatus.

Claims

1. A medical apparatus comprising:

a housing having a size and shape adapted for implantation in a subject;

therapy means disposed in said housing for producing a medical therapy regimen;

means connected to said therapy means and adapted for interaction with the subject for delivering said medical therapy regimen in vivo to the subject;

sensor means adapted for interaction with the subject for obtaining an electrical signal representing physiological activity of the subject;

signal analysis means disposed in said housing and connected to said sensor means, for performing detrended fluctuation analysis of said electrical signal and thereby obtaining a self-similarity parameter for said electrical signal; and

means for making said self-similarity parameter extracorporeally available.

2. A medical apparatus as claimed in claim 1 wherein said therapy means comprise means for emitting cardiac pacing pulses.

3. A medical apparatus as claimed in claim 1 wherein said sensor means comprise means for obtaining an electrical signal representing ventricular electrical activity.

4. A medical apparatus as claimed in claim 1 wherein said sensor means comprise means for obtaining an electrical signal representing ventricular blood pressure.

5. A medical apparatus as claimed in claim 1 further comprising means for sampling said electrical signal to obtain a total number of samples;

means for separately integrating said electrical signal over said total number of samples and over a plurality of subsets of said total number of samples, each subset containing a different number of samples, each integration producing an integration curve having an integral value YINT;

means, for each integration curve, fitting a best fit straight line thereto and for identifying a linear trend YLIN for that best fit straight line;

means, for each associated integral value YINT and linear trend YLIN, for calculating a value F according to the formula ##EQU2## wherein N is the number of samples for the integral curve which produced YINT and YLIN; and

means for identifying a further best fit straight line for all values of F for said electrical signal, said further best fit straight line having a slope comprising said self-similarity parameter.

6. A medical apparatus comprising:

a housing having a size and shape adapted for implantation in a subject;

therapy means disposed in said housing for producing a medical therapy regimen;

means connected to said therapy means and adapted for interaction with the subject for delivering said medical therapy regimen in vivo to the subject;

sensor means adapted for interaction with the subject for obtaining an electrical signal representing physiological activity of the subject;

signal analysis means disposed in said housing and connected to said sensor means, for performing detrended fluctuation analysis of said electrical signal and thereby obtaining a self-similarity parameter for said electrical signal; and

control means for controlling production of said medical therapy regimen by said therapy means dependent on said self-similarity parameter.

7. A medical apparatus as claimed in claim 6 wherein said control means comprises means for comparing said electrical signal to a reference value and means for adjusting said reference value dependent on said self-similarity parameter.

8. A medical apparatus as claimed in claim 6 wherein said control means comprises means for comparing a value derived from said electrical signal to a reference value and means for adjusting said reference value dependent on said self-similarity parameter.

9. A medical apparatus as claimed in claim 6 wherein said therapy means comprise means for emitting cardiac pacing pulses.

10. A medical apparatus as claimed in claim 6 wherein said sensor means comprise means for obtaining an electrical signal representing ventricular electrical activity.

11. A medical apparatus as claimed in claim 6 wherein said sensor means comprise means for obtaining an electrical signal representing ventricular blood pressure.

12. A medical apparatus as claimed in claim 6 further comprising means for sampling said electrical signal to obtain a total number of samples;

means for separately integrating said electrical signal over said total number of samples and over a plurality of subsets of said total number of samples, each subset containing a different number of samples, each integration producing an integration curve having an integral value YINT;

means, for each integration curve, fitting a best fit straight line thereto and for identifying a linear trend YLIN for that best fit straight line;

means, for each associated integral value YINT and linear trend YLIN, for calculating a value F according to the formula ##EQU3## wherein N is the number of samples for the integral curve which produced YINT and YLIN; and

means for identifying a further best fit straight line for all values of F for said electrical signal, said further best fit straight line having a slope comprising said self-similarity parameter.

13. A cardiac pacemaker comprising:

a housing having a size and shape adapted for implantation in a subject;

pulse generator means disposed in said housing for emitting a pacing regimen comprising a plurality of pacing pulses;

an electrode lead connected to said pulse generator means and terminating in at least one electrode for interaction with said subject for delivering said pacing pulses in vivo to said subject;

sensor means adapted for interaction with the subject for obtaining at least one electrical signal representing physiological activity of the subject;

signal analysis means disposed in said housing and connected to said sensor means for performing detrended fluctuation analysis of said electrical signal and thereby obtaining a self-similarity parameter for said electrical signals; and

telemetry means in said housing for making said self-similarity parameter extracorporeally available.

14. A cardiac pacemaker as claimed in claim 13 wherein said sensor means comprise a ring electrode on said electrode lead for obtaining an electrical signal representing ventricular electrical activity.

15. A cardiac pacemaker as claimed in claim 13 wherein said sensor means comprise a pressure sensor for obtaining an electrical signal representing ventricular blood pressure.

16. A cardiac pacemaker as claimed in claim 13 wherein said sensor means comprise means for obtaining a first electrical signal representing a first physiological activity of the subject and means for obtaining a second electrical signal representing a second physiological activity of the subject, and switching means for supplying a selected one of said first and second electrical signals to said signal analysis means.

17. A cardiac pacemaker as claimed in claim 13 wherein said sensor means comprise means for obtaining a first electrical signal representing a first physiological activity of the subject and means for obtaining a second electrical signal representing a second physiological activity of the subject, and switching means for alternatively supplying said first and second electrical signals to said signal analysis means.

18. A cardiac pacemaker as claimed in claim 13 further comprising:

control means for adjusting said pacing regimen generated by said pulse generator means dependent on said self-similarity parameter.

19. A cadiac pacemaker as claimed in claim 18 wherein said control means comprises means for comparing said electrical signal to a reference value and means for adjusting said reference value dependent on said self-similarity parameter.

20. A caridac pacemaker as claimed in claim 18 wherein said control means comprises means for comparing a value derived from said electrical signal to a reference value and means for adjusting said reference value dependent on said self-similarity parameter.

21. A cardiac pacemaker as claimed in claim 13 wherein said therapy means comprise means for emitting cardiac pacing pulses.

22. A cardiac pacemaker as claimed in claim 13 wherein said sensor means comprises means for obtaining an electrical signal representing ventricular electrical activity.

23. A cardiac pacemaker as claimed in claim 13 wherein said sensor means comprise means for obtaining an electrical signal representing ventricular blood pressure.

24. A cardiac pacemaker as claimed in claim 13 further comprising means for sampling said electrical signal to obtain a total number of samples;

means for separately integrating said electrical signal over said total number of samples and over a plurality of subsets of said total number of samples, each subset containing a different number of samples, each integration producing an integration curve having an integral value YINT;

means, for each integration curve, fitting a best fit straight line thereto and for identifying a linear trend YLIN for that best fit straight line;

means, for each associated integral value YINT and linear trend YLIN, for calculating a value F according to the formula ##EQU4## wherein N is the number of samples for the integral curve which produced YINT and YLIN; and

means for identifying a further best fit straight line for all values of F for said electrical signal, said further best fit straight line having a slope comprising said self-similarity parameter.