Blood processing systems and methods which monitor citrate return to the donor
First Claim
1. A blood processing system comprisinga separation device,an inlet path including a pump operable at a prescribed rate Qb constructed and arranged to convey whole blood from an individual donor into the separation device for separation into components including red blood cells and a plasma constituent,an anticoagulant including a citrate concentration added to the whole blood,a controller coupled to the inlet path pump operative to control Qb (in ml/min or equivalent) based at least in part upon a citrate equivalent blood flow rate EqQbCIR, where:
- ##EQU33## where;
CIR is a nominal a-symptomatic citrate infusion rate (in mg/kg/min or equivalent), empirically selected based upon citrate reactions in a population of different donors,AC is a selected anticoagulant ratio,Wgt is the individual donor'"'"'s weight (in kg or equivalent), andCitrateConc is the citrate concentration in the anticoagulant (in mg/ml or equivalent), andan outlet path constructed and arranged to return at least a portion of component containing anticoagulant from the separation device to the individual donor.
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Accused Products
Abstract
Blood collection systems and methods minimize citrate toxicity in donors. The systems and methods convey whole blood at a prescribed rate Qb into a separation device for separation into red blood cells and a plasma constituent. The systems and methods add anticoagulant including citrate to the whole blood. The systems and methods control Qb (in ml/min or equivalent) based upon a citrate equivalent blood flow rate EqQBCIR, where: ##EQU1## where: CIR is a selected nominal a-symptomatic citrate infusion rate (in mg/kg/min or equivalent),
AC is a selected anticoagulant ratio,
Wgt is the donor'"'"'s weight (in kg or equivalent), and
CitrateConc is the citrate concentration in the anticoagulant (in mg/ml or equivalent).
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Citations
14 Claims
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1. A blood processing system comprising
a separation device, an inlet path including a pump operable at a prescribed rate Qb constructed and arranged to convey whole blood from an individual donor into the separation device for separation into components including red blood cells and a plasma constituent, an anticoagulant including a citrate concentration added to the whole blood, a controller coupled to the inlet path pump operative to control Qb (in ml/min or equivalent) based at least in part upon a citrate equivalent blood flow rate EqQbCIR, where: - ##EQU33## where;
CIR is a nominal a-symptomatic citrate infusion rate (in mg/kg/min or equivalent), empirically selected based upon citrate reactions in a population of different donors,AC is a selected anticoagulant ratio, Wgt is the individual donor'"'"'s weight (in kg or equivalent), and CitrateConc is the citrate concentration in the anticoagulant (in mg/ml or equivalent), and an outlet path constructed and arranged to return at least a portion of component containing anticoagulant from the separation device to the individual donor. - View Dependent Claims (2, 3)
- ##EQU33## where;
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4. A blood processing system comprising
a separation device, an inlet path including a pump operable at a prescribed rate Qb constructed and arranged to convey whole blood from an individual donor into the separation device for separation into components including red blood cells and a plasma constituent, an anticoagulant including a concentration of citrate added to the whole blood, a controller coupled to the inlet path pump to control Qb (in ml/min or equivalent), where: - ##EQU34## and where;
Hb is a value reflecting anticoagulated hematocrit of the whole blood conveyed into the separation device,VbRem is a value reflecting a remaining volume of whole blood to be processed, PPPGoal is a value reflecting a plasma constituent volume collection goal (in ml or equivalent), PPPCurrent is a value reflecting a current collected plasma constituent volume (in ml or equivalent), and EqQbCIR is a value reflecting citrate equivalent blood flow rate (in ml/min or equivalent), calculated as follows;
##EQU35## where;
CIR is a nominal a-symptomatic citrate infusion rate (in mg/kg/min or equivalent), empirically selected based upon citrate reactions in a population of different donors,AC is a selected anticoagulant ratio, Wgt is the individual donor'"'"'s weight (in kg or equivalent), and CitrateConc is the citrate concentration in the selected anticoagulant (in mg/ml or equivalent), and an outlet path constructed and arranged to return at least a portion of component containing anticoagulant from the separation device to the individual donor. - View Dependent Claims (5, 6, 7, 8)
- ##EQU34## and where;
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9. A blood processing method comprising the steps of
conveying whole blood at a prescribed rate Qb from an individual donor into a separation device for separation into red blood cells and a plasma constituent, adding anticoagulant including a concentration of citrate to the whole blood, controlling Qb in ml/min or equivalent) based upon a citrate equivalent blood flow rate EqQbCIR where: - ##EQU39## where;
CIR is a nominal a-symptomatic citrate infusion rate (in mg/kg/min or equivalent), empirically selected based upon citrate reactions in a population of different donors,AC is a selected anticoagulant ratio, Wgt is the individual donor'"'"'s weight (in kg or equivalent), and CitrateConc is the citrate concentration in the anticoagulant (in mg/ml or equivalent), and returning at least a portion of component containing anticoagulant from the separation device to the donor. - View Dependent Claims (10)
- ##EQU39## where;
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11. A blood processing method comprising the steps of
conveying whole blood at a prescribed rate Qb from an individual donor into the separation device for separation into red blood cells and a plasma constituent, adding an anticoagulant including a concentration of citrate to the whole blood, controlling Qb (in ml/min or equivalent), where: - ##EQU40## and where;
Hb is a value reflecting anticoagulated hematocrit of the whole blood conveyed into the separation device,VbRem is a value reflecting a remaining volume of whole blood to be processed, PPPGoal is a value reflecting a plasma constituent volume collection goal (in ml or equivalent), PPPCurrent is a value reflecting a current collected plasma constituent volume (in ml or equivalent), and EqQbCIR is a value reflecting citrate equivalent blood flow rate (in ml/min or equivalent), calculated as follows;
##EQU41## where;
CIR is a nominal a-symptomatic citrate infusion rate (in mg/kg/min or equivalent), empirically selected based upon citrate reactions in a population of different donors,AC is a selected anticoagulant ratio, Wgt is the individual donor'"'"'s weight (in kg or equivalent), and CitrateConc is the citrate concentration in the selected anticoagulant (in mg/ml or equivalent), and returning at least a portion of component containing anticoagulant from the separation device to the donor. - View Dependent Claims (12, 13, 14)
- ##EQU40## and where;
Specification