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Monoclonal antibodies directed to the HER2 receptor

  • US 5,677,171 A
  • Filed: 08/05/1994
  • Issued: 10/14/1997
  • Est. Priority Date: 01/12/1988
  • Status: Expired due to Term
First Claim
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1. A monoclonal antibody which specifically binds to the extracellular domain of the HER2 receptor and inhibits growth of SK-BR-3 breast tumor cells in cell culture by greater than 20%, at an antibody concentration on of 0.5-30 μ

  • g/ml, wherein said SK-BR-3 cells are cultured in culture medium comprising 10% fetal bovine serum and said growth inhibition is determined six days after exposure of said SK-BR-3 cells to said antibody.

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