Method and apparatus for detecting blood pressure by blood pressure sounds in the presence of significant noise

• US 5,680,868 A
• Filed: 06/17/1996
• Issued: 10/28/1997
• Est. Priority Date: 06/17/1996
• Status: Expired due to Fees

• Current Assignee: Bpsure LLC
• Original Assignee: Bpsure LLC
• Inventors: Kahn, Alan R., Bahr, Dennis E., Allen, Kurt W.
• Primary Examiner(s): NASSER, ROBERT L
• Application Number:
  US08/665,286
• Time in Patent Office: 498 Days
• Field of Search: 128/677, 128/680-3, 128/687
• US Class Current: 600/494
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02208 using the Korotkoff method
• CPC Class Codes: A61B 7/045 Detection of Korotkoff sounds A61B5/0225 takes precedence; measuring blood pressure A61B5/021

Abstract

A method and apparatus is provided for detecting blood pressure sounds produced by the opening snap of an artery in a patient in the presence of significant noise using the phase information contained in two microphone signals. The two microphones are placed on a patient along the axis of an artery with their centers separated by a distance such that blood pressure sounds picked up by the microphones will be out of phase. Pressure is applied to the artery such that the artery opens and closes during each heart cycle, the opening snap of the artery producing blood pressure sounds. The two microphone signals are filtered, preferably using band pass filters having pass bands corresponding to the frequency of the blood pressure sounds. The filtered microphone signals are sampled and multiplied together or convolved in the frequency domain to generate a microphone signal product. If the microphone signal product is negative, the detection of a valid blood pressure signal for that sampling time is indicated. In an alternative embodiment, the slope of the two microphone signals at the sample time is also determined. A valid blood pressure signal is indicated when the microphone signal product is negative and either the two microphone signal slopes have inverse signs or are both less than a selected slope threshold. A selected number of consecutive valid blood pressure signal detections indicates the detection of a blood pressure sound. The detection of blood pressure sounds at a range of cuff pressures is used to determine the systolic and diastolic blood pressure levels of the patient.

Claims

1. A method for detecting a blood pressure sound in a patient, comprising the steps of:

(a) placing a first microphone on the patient near the location of an artery, the first microphone producing a first microphone signal in response to blood pressure sounds and noise picked up by the first microphone;

(b) placing a second microphone on the patient having a center separated a distance from a center of the first microphone such that a blood pressure sound picked up by the first microphone will be picked up out of phase by the second microphone, the second microphone producing a second microphone signal in response to blood pressure sounds and noise picked up by the second microphone;

(c) applying pressure to the artery such that the artery will be forced closed during part of a heart beat cycle and will be forced open during part of the heart beat cycle when the patient'"'"'s blood pressure exceeds the pressure applied to the artery, the opening of the artery causing a blood pressure sound to be produced;

(d) selecting portions of the first and second microphone signals having characteristics corresponding to blood pressure sounds;

(e) multiplying the selected portions of the first and second microphone signals at selected points in time to generate a microphone signal product; and

(f) indicating the detection of a blood pressure sound when the microphone signal product is negative for multiple consecutive selected points in time corresponding to a selected time period.

2. The method of claim 1 wherein the step of indicating the detection of a blood pressure sound indicates the detection of a blood pressure sound when the microphone signal product is negative for multiple consecutive selected points in time corresponding to a selected time period of approximately 2.5 milliseconds.

3. The method of claim 1 comprising additionally the steps of preventing further indications of the detection of a blood pressure sound for a selected pause period after the indication of the detection of a blood pressure sound, and repeating the steps of selecting portions of the microphone signals, multiplying the microphone signals, and indicating the detection of a blood pressure sound after the selected pause period has ended.

4. The method of claim 3 wherein the selected pause period is approximately 100 milliseconds.

5. The method of claim 1 wherein the center of the second microphone is placed on the patient separated a distance from the center of the first microphone such that the blood pressure sound picked up by the first microphone will be picked up approximately 180 degrees out of phase by the second microphone.

6. The method of claim 5 wherein the center of the second microphone is placed on the patient separated by a distance of approximately 2.5 centimeters from the center of the first microphone.

7. The method of claim 1 wherein the step of applying pressure to the artery includes the step of inflating an inflatable cuff wrapped around an arm of the patient and wherein the first and second microphones are placed on the arm of the patient under the inflatable cuff near a down stream end of the cuff and along an axis of the artery.

8. The method of claim 7 wherein the first and second microphones are fixed in the inflatable cuff.

9. The method of claim 1 wherein the step of selecting portions of the first and second microphone signals includes the step of filtering the first and second microphone signals with filters having pass bands corresponding approximately to the frequency range of the blood pressure sound.

10. The method of claim 9 wherein the step of filtering the first and second microphone signals includes the step of filtering the first and second microphone signals with band pass filters having pass bands of approximately 30 Hz to 80 Hz.

11. The method of claim 1 wherein the step of multiplying the selected portions of the microphone signals includes the step of sampling the microphone signals at selected sampling points in time and multiplying the sampled microphone signals to generate the microphone signal product.

12. The method of claim 11 wherein the step of sampling the microphone signals at selected sampling points in time is performed at a sampling rate of between approximately 500 samples per second and approximately 2000 samples per second.

13. The method of claim 1 wherein the step of multiplying the selected portions of the microphone signals includes the steps of converting the first and second microphone signals to the frequency domain and then convolving the frequency domain spectra of the first and second microphone signals.

14. The method of claim 1 wherein the step of indicating the detection of a blood pressure sound indicates a blood pressure sound when the microphone signal product is negative and the absolute value of the microphone signal product exceeds a minimal noise threshold for multiple consecutive selected points in time corresponding to the selected time period.

15. The method of claim 1 comprising additionally the steps of determining slopes of the selected portions of the first and second microphone signals at the selected points in time and indicating the detection of a blood pressure sound when the microphone signal product is negative and either the slopes of the first and second microphone signals have inverse signs or the slopes of the first and second microphone signals are both less than a selected slope threshold at the selected point in time for multiple consecutive selected points in time corresponding to the selected time period.

16. A method for detecting blood pressure by blood pressure sounds in a patient, comprising the steps of:

(a) placing a first microphone on the patient near the location of an artery, the first microphone producing a first microphone signal in response to blood pressure sounds and noise picked up by the first microphone;

(b) placing a second microphone on the patient having a center separated a distance from a center of the first microphone such that a blood pressure sound picked up by the first microphone will be picked up out of phase by the second microphone, the second microphone producing a second microphone signal in response to blood pressure sounds and noise picked up by the second microphone;

(c) applying pressure to the artery at a plurality of pressure levels ranging from above a systolic blood pressure level of the patient to below a diastolic blood pressure level of the patient, the artery being forced open during part of the heart beat cycle when the patient'"'"'s blood pressure exceeds the pressure applied to the artery, the opening of the artery causing a blood pressure sound to be produced;

(d) selecting portions of the first and second microphone siqnals having characteristics corresponding to blood pressure sounds;

(e) multiplying the selected portions of the first and second microphone siqnals at selected points in time to generate a microphone signal product;

(f) indicating the detection of a blood pressure sound when the microphone signal product is negative for multiple consecutive selected points in time corresponding to a selected time period;

(g) repeating the steps of selecting portions of the microphone signals, multiplying the microphone signals, and indicating the detection of a blood pressure sound at each of the plurality of pressure levels; and

(h) displaying a systolic blood pressure level of the patient as a highest of the plurality of pressure levels at which a blood pressure sound is indicated as being detected and displaying a diastolic blood pressure level of the patient as a lowest of the plurality of pressure levels at which a blood pressure sound is indicated as being detected.

17. The method of claim 16 wherein the step of applying pressure to the artery at a plurality of pressure levels includes the step of slowly reducing pressure in an inflatable cuff from above a maximum probable systolic blood pressure level of the patient to a pressure level below the diastolic blood pressure level of the patient at which blood pressure sounds are no longer indicated as being detected to apply the plurality of pressure levels.

18. The method of claim 16 wherein the step of applying pressure to the artery at a plurality of pressure levels includes the step of slowly increasing pressure in an inflatable cuff from below the minimum probable diastolic blood pressure level of the patient to a pressure level above the systolic blood pressure level of the patient at which blood pressure sounds are no longer indicated as being detected to apply the plurality of pressure levels.

19. A method for detecting a blood pressure sound in a patient, comprising the steps of:

(a) placing a first microphone on the patient near the location of an artery, the first microphone producing a first microphone signal in response to blood pressure sounds and noise picked up by the first microphone;

(b) placing a second microphone on the patient having a center separated a distance from a center of the first microphone such that a blood pressure sound picked up by the first microphone will be picked up out of phase by the second microphone, the second microphone producing a second microphone signal in response to blood pressure sounds and noise picked up by the second microphone;

(c) applying pressure to the artery such that the artery will be forced closed during part of a heart beat cycle and will be forced open during part of the heart beat cycle when the patient'"'"'s blood pressure exceeds the pressure applied to the artery, the opening of the artery causing a blood pressure sound to be produced;

(d) filtering the first and second microphone signals with band pass filters having pass bands corresponding approximately to the frequency range of the blood pressure sound;

(e) multiplying the filtered first and second microphone signals at selected points in time to generate a microphone signal product;

(f) indicating the detection of a valid blood pressure signal when the microphone signal product is negative; and

(g) indicating the detection of a blood pressure sound when the detection of valid blood pressure signals are indicated for multiple consecutive selected points in time corresponding to a selected time period.

20. The method of claim 19 wherein the step of indicating the detection of a blood pressure sound indicates the detection of a blood pressure sound when valid blood pressure signals are detected for multiple consecutive selected points in time corresponding to a selected time period of approximately 2.5 milliseconds.

21. The method of claim 19 comprising additionally the steps of preventing further indications of the detection of a blood pressure sound for a selected pause period after the indication of the detection of a blood pressure sound, and repeating the steps of filtering the microphone signals, multiplying the microphone signals, indicating the detection of valid blood pressure signals, and indicating the detection of a blood pressure sound after the selected pause period has ended.

22. The method of claim 21 wherein the selected pause period is approximately 100 milliseconds.

23. The method of claim 19 wherein the center of the second microphone is placed on the patient separated a distance from the center of the first microphone such that the blood pressure sound picked up by the first microphone will be picked up approximately 180 degrees out of phase by the second microphone.

24. The method of claim 23 wherein the center of the second microphone is placed on the patient separated by a distance of approximately 2.5 centimeters from the center of the first microphone.

25. The method of claim 19 wherein the step of applying pressure to the artery includes the step of inflating an inflatable cuff wrapped around an arm of the patient and wherein the first and second microphones are placed on the arm of the patient under the inflatable cuff near a down stream end of the cuff and along an axis of the artery.

26. The method of claim 25 wherein the first and second microphones are fixed in the inflatable cuff.

27. The method of claim 19 wherein the step of filtering the first and second microphone signals includes the step of filtering the first and second microphone signals with band pass filters having a pass bands of approximately 30 Hz to 80 Hz.

28. The method of claim 19 wherein the step of multiplying the filtered microphone signals includes the step of sampling the microphone signals at selected sampling points in time and multiplying the sampled microphone signals to generate the microphone signal product.

29. The method of claim 28 wherein the step of sampling the microphone signals at selected sampling points in time is performed at a sampling rate of between approximately 500 samples per second and approximately 2000 samples per second.

30. The method of claim 19 wherein the step of multiplying the filtered microphone signals includes the steps of converting the first and second microphone signals to the frequency domain and then convolving the frequency domain spectra of the microphone signals.

31. A method for detecting blood pressure by blood pressure sounds in a patient, comprising the steps of:

(a) placing a first microphone on the patient near the location of an artery, the first microphone producing a first microphone signal in response to blood pressure sounds and noise picked up by the first microphone;

(b) placing a second microphone on the patient having a center separated a distance from a center of the first microphone such that a blood pressure sound picked up by the first microphone will be picked up out of phase by the second microphone, the second microphone producing a second microphone signal in response to blood pressure sounds and noise picked up by the second microphone;

(c) applying pressure to the artery at a plurality of pressure levels ranging from above a systolic blood pressure level of the patient to below a diastolic blood pressure level of the patient, the artery being forced open during part of the heart beat cycle when the patient'"'"'s blood pressure exceeds the pressure applied to the artery, the opening of the artery causing a blood pressure sound to be produced;

(d) filtering the first and second microphone signals with band pass filters having pass bands corresponding approximately to the frequency range of the blood pressure sound;

(e) multiplying the filtered first and second microphone signals at selected points in time to generate a microphone signal product;

(f) indicating the detection of a valid blood pressure signal when the microphone signal product is negative;

(g) indicating the detection of a blood pressure sound when the detection of valid blood pressure signals are indicated for multiple consecutive selected points in time corresponding to a selected time period;

(h) repeating the steps of filtering the microphone signals, multiplying the microphone signals, indicating the detection of a valid blood pressure signal, and indicating the detection of a blood pressure sound at each of the plurality of pressure levels; and

(i) displaying a systolic blood pressure level of the patient as a highest of the plurality of pressure levels at which a blood pressure sound is indicated as being detected and displaying a diastolic blood pressure level of the patient as a lowest of the plurality of pressure levels at which a blood pressure sound is indicated as being detected.

32. The method of claim 31 wherein the step of applying pressure to the artery at a plurality of pressure levels includes the step of slowly reducing pressure in an inflatable cuff from above a maximum probable systolic blood pressure level of the patient to a pressure level below the diastolic blood pressure level of the patient at which blood pressure sounds are no longer indicated as being detected to apply the plurality of pressure levels.

33. The method of claim 31 wherein the step of applying pressure to the artery at a plurality of pressure levels includes the step of slowly increasing pressure in an inflatable cuff from below the minimum probable diastolic blood pressure level of the patient to a pressure level above the systolic blood pressure level of the patient at which blood pressure sounds are no longer indicated as being detected to apply the plurality of pressure levels.

34. A method for detecting a valid blood pressure sound signal in a patient, comprising the steps of:

(a) placing a first microphone on the patient near the location of an artery, the first microphone producing a first microphone signal in response to blood pressure sounds and noise picked up by the first microphone;

(b) placing a second microphone on the patient having a center separated a distance from a center of the first microphone such that a blood pressure sound picked up by the first microphone will be picked up out of phase by the second microphone, the second microphone producing a second microphone signal in response to blood pressure sounds and noise picked up by the second microphone;

(c) applying pressure to the artery such that the artery will be forced closed during part of a heart beat cycle and will be forced open during part of the heart beat cycle when the patient'"'"'s blood pressure exceeds the pressure applied to the artery, the opening of the artery causing a blood pressure sound to be produced;

(d) filtering the first and second microphone signals with a filter having a pass band corresponding approximately to the frequency range of the blood pressure sound;

(e) multiplying the filtered first and second microphone signals at selected points in time to generate a microphone signal product;

(f) determining slopes of the first and second filtered microphone signals at the selected points in time; and

(g) indicating the detection of a blood pressure sound when the microphone signal product is negative and either the slopes of the first and second microphone signals have inverse signs or the slopes of the first and second microphone signals are both less than a selected slope threshold value for multiple selected points in time corresponding to a selected time period.

35. An apparatus for detecting blood pressure sounds in a patient, comprising:

(a) an inflatable cuff adapted to be wrapped around a limb of a patient;

(b) a first microphone fixed in the inflatable cuff, the first microphone producing a first microphone signal in response to blood pressure sounds and noise picked up by the first microphone;

(c) a second microphone fixed in the inflatable cuff and having a center separated a distance from a center of the first microphone such that a blood pressure sound picked up by the first microphone will be picked up out of phase by the second microphone, the second microphone producing a second microphone signal in response to blood pressure sounds and noise picked up by the second microphone;

(d) means for inflating the inflatable cuff to thereby apply pressure to the limb of a patient such that an artery in the patient'"'"'s limb will be forced closed during part of a heart beat cycle and will be forced open during part of the heart beat cycle when the patient'"'"'s blood pressure exceeds the pressure applied to the artery, the opening of the artery causing a blood pressure sound to be produced;

(e) means for selecting portions of the first and second microphone signals having characteristics corresponding to blood pressure sounds;

(f) means for multiplying the selected portions of the first and second microphone signals at selected points in time to generate a microphone signal product;

(g) means for indicating the detection of a valid blood pressure signal when the microphone signal product is negative; and

(h) means for indicating the detection of a blood pressure sound when the detection of valid blood pressure signals are indicated for multiple consecutive selected points in time corresponding to a selected time period.

36. The apparatus for detecting blood pressure sounds of claim 35 wherein the centers of the first and second microphones are separated by a distance such that the blood pressure sound picked up by the first microphone will be picked up approximately 180 degrees out of phase by the second microphone.

37. The apparatus for detecting blood pressure sounds of claim 36 wherein the centers of the first and second microphones are separated by a distance of approximately 2.5 centimeters.

38. The apparatus for detecting blood pressure sounds of claim 35 wherein the means for selecting portions of the first and second microphone signals includes band pass filters having pass bands corresponding approximately to the frequency range of the blood pressure sound.

39. The apparatus for detecting blood pressure sounds of claim 38 wherein the band pass filters have pass bands of approximately 30 Hz to 80 Hz.

40. The apparatus for detecting blood pressure sounds of claim 35 including means for sampling the filtered microphone signals at a sampling rate of between approximately 500 samples per second and approximately 2000 samples per second and means for multiplying the sampled microphone signals to generate the microphone signal product.

41. The apparatus for detecting blood pressure sounds of claim 35 wherein the means for multiplying the selected portions of the microphone signals includes means for converting the first and second microphone signals to the frequency domain and for convolving the frequency domain spectra of the first and second microphone signals.

42. The apparatus for detecting blood pressure sounds of claim 35 wherein the selected time period is approximately 2.5 milliseconds.

43. The apparatus for detecting blood pressure sounds of claim 35 comprising additionally means for determining slopes of the selected portions of the first and second microphone signals at the selected points in time and means for indicating the detection of a valid blood pressure signal when the microphone signal product is negative and either the slopes of the first and second microphone signals have inverse signs or the slopes of the first and second microphone signals are both less than a selected slope threshold.

44. An apparatus for detecting blood pressure by blood pressure sounds in a patient, comprising:

(a) an inflatable cuff adapted to be wrapped around a limb of a patient;

(b) a first microphone fixed in the inflatable cuff, the first microphone producing a first microphone signal in response to blood pressure sounds and noise picked up by the first microphone;

(c) a second microphone fixed in the inflatable cuff and having a center separated a distance from a center of the first microphone such that a blood pressure sound picked up by the first microphone will be picked up out of phase by the second microphone, the second microphone producing a second microphone signal in response to blood pressure sounds and noise picked up by the second microphone;

(d) means for inflating and deflating the inflatable cuff to apply pressure to the limb of the patient at a plurality of pressure levels ranging from above a systolic blood pressure level of the patient to below a diastolic blood pressure level of the patient, an artery in the patient'"'"'s limb being forced open during part of the heart beat cycle when the patient'"'"'s blood pressure exceeds the pressure applied to the artery, the opening of the artery causing a blood pressure sound to be produced;

(e) means for selecting portions of the first and second microphone siqnals having characteristics corresponding to blood pressure sounds;

(f) means for multiplying the selected portions of the first and second microphone siqnals at selected points in time to generate a microphone signal product;

(g) means for indicating the detection of a valid blood pressure signal when the microphone signal product is negative;

(h) means for indicating the detection of a blood pressure sound when the detection of valid blood pressure signals are indicated for multiple consecutive selected points in time corresponding to a selected time period;

(i) means for measuring the cuff pressure at each of the plurality of pressure levels;

(j) means for selecting portions of the microphone signals, multiplying the microphone signals, indicating the detection of a valid blood pressure signal, and indicating the detection of a blood pressure sound at each of the plurality of pressure levels; and

(k) means for displaying a systolic blood pressure level of the patient as a highest of the measured cuff pressure levels at which a blood pressure sound is indicated as being detected and displaying a diastolic blood pressure level of the patient as a lowest of the measured cuff pressure levels at which a blood pressure sound is indicated as being detected.

45. The apparatus for detecting blood pressure sounds of claim 44 wherein the means for measuring the cuff pressure includes a pressure transducer.