Disposable auto-injector for prefilled syringes

• US 5,681,291 A
• Filed: 07/20/1995
• Issued: 10/28/1997
• Est. Priority Date: 11/19/1992
• Status: Expired due to Term

• Current Assignee: TEBRO SA
• Original Assignee: TEBRO SA
• Inventors: Galli, Rosaria
• Primary Examiner(s): Rimell, Sam
• Assistant Examiner(s): Racunas, Robert V.
• Application Number:
  US08/446,614
• Time in Patent Office: 831 Days
• Field of Search: 604/192, 604/198, 604/263, 604/162, 604/156
• US Class Current: 604/192
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/3247 Means to impede repositioning of protection sleeve from needle covering to needle uncovering position
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3243 being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel devices for protecting guide needles in combination with catheters A61M25/0612
• CPC Class Codes: A61M 5/326 Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion

Abstract

An auto-injector for a medicament prefilled syringe, having a head at one end and fitted with a needle at the other end, the auto-injector incorporating a first device D1 which makes automatic the needle penetration into the user'"'"'s body and controls a second device D2 which performs the medicament injection. The first device includes: a cylindrical body (1) formed for receiving a syringe (4) and provided at its upper end with a collar forming a seat suitable to bear the head of the syringe, and a sliding tubular element or slider (5) concentric to the body and adapted to slide on a cylindrical surface of the body. One of the body (1) and slider (5) is formed with a bevelled projection and the other of the body (1) and slider (5) is formed with a shoulder (11). A resilient ring (9) is arranged in such a way that ring (9) prevents the reciprocal movement of body (1) and slider (5) thus maintaining the latter in such a position to cover the entire needle (10) of the syringe. The resilient ring is designed for spreading when a predetermined force exerted on the slider is reached and so allowing reciprocal movement of body and shoulder, the slider reaching a position in which the needle is uncovered and penetrates into the user'"'"'s body. The slider is fitted with an appendix disposed for releasing a triggering device on the second device when the reciprocal movement is completed.

Claims

1. An auto-injector for a medicament prefilled syringe (4), having a head at one end and fitted with a needle at the other end and including a syringe piston (23), said auto-injector incorporating a first device D1 which makes automatic the needle penetration into a user'"'"'s body and controls a second device D2 which performs the medicament injection, said first device D1 comprising:

a cylindrical body (1) formed for receiving the syringe (4), said cylindrical body being provided at an upper end with a collar forming a seat suitable to bear the head of the syringe,

a slider (5) concentric to said body and adapted to slide on a cylindrical surface of said body,

a first trigger means (9) arranged such that a reciprocal movement of said body and said slider is prevented, thus maintaining the slider in a position to cover the entire needle (10) of the syringe, the first trigger means being releasable when a predetermined force is exerted on said slider, thus allowing reciprocal movement of said body and said slider, said slider reaching a position whereat said needle is uncovered and penetrates into the user'"'"'s body,

said second device D2 comprising;

a piston (21), resting against the syringe piston (23) and urged by a compressed spring (22),

a second trigger means (19), retaining said piston (21), wherein one of said body and said slider is formed with a bevelled projection and the other of said body and said slider is formed with a shoulder (11), said first trigger means (9) being partly placed between said projection and said shoulder, said slider (5) of said first device D1 being fitted with an appendix disposed for releasing said second trigger-means (19) of said second device (D2) when said reciprocal movement of said body (1) and said slider (5) is completed with the result of having the medicament injection beginning only after the complete needle penetration thereby avoiding any medicament delivery at a non-desired depth or site.

2. An auto-injector according to claim 1, wherein said second device comprises a casing (14) formed with a bore and having a lower open end and a closed upper bottom, said lower open end of said casing being fixed to the upper end of said body, (1) by connecting means (12, 13), said casing housing the piston (21) axially sliding into said bore, resting against the syringe piston (23) and urged, on its opposite side, by a spring (22), compressed between said closed bottom and said piston, said piston being retained by said second trigger means (19), said appendix of said slider (5) being formed by an upper extended part of said slider (5) with an upper edge, said second trigger means (19) being adapted to be released by said upper edge.

3. An auto-injector according to claim 2, wherein said second trigger means (19) comprises at least one detent tooth, projecting into said bore of said casing (14) for retaining said piston, means for urging said at least one tooth out of said bore, and said at least one tooth being maintained in said bore by means of a control sleeve (17) movable between two positions:

one lower position in which said control sleeve (17) prevents said at least one tooth from getting out from said bore, and an upper position in which said at least one tooth is free to get out of said bore, said upper edge of said slider (5) being at a length such that, when said slider is about to completely uncover said needle, said upper edge engages said control sleeve (17) in the lower position and moves it upwards to the upper position.

4. An auto-injector according to claim 2, which further comprises a tubular protection cover (24) fixed to an upper end of casing (14),for covering said second device performing the injection.

5. An auto-injector according to claim 2, wherein said first trigger means (9) of said first device D1 comprise a detent slit ring (9) having one single slit, automatic safety needle protection means are provided, said protection means including an elastic sleeve (31) placed around said casing (14) and movable between a lower position and an upper position, a seat (35) formed on the upper part of said slider, for receiving said elastic sleeve in a deformed state in its lower position, a return spring (36) for moving back said slider in its initial position after completion of the injection when said auto-injector is moved away from the user'"'"'s body, at least one part of said elastic sleeve being in pressure contact with one of said casing (14) and said protection cover (24) so that friction so provided is light enough not to prevent a snap rearward movement of said slider, but high enough to cause a friction force which is greater than a friction force against the seat (35), so that during said snap movement, said elastic sleeve is pushed upwards to the upper position and when the slider is pushed back by the return spring, the elastic sleeve remains in said upper position, the length of said elastic sleeve being slightly shorter than the stroke of the slider, whereby said elastic sleeve completely gets out from said seat (35) and returns to its free state, thus irreversibly locking said slider into a needle protection position.

6. An auto-injector according to claim 1, wherein said slider (5) is disposed outside and around said cylindrical body (1).

7. An auto-injector according to claim 2, wherein said connecting means comprise flexible teeth (13) on the lower end of said casing (14) and sloes (12) on the cylindrical carrying body (1).

8. An auto-injector according to claim 3, wherein said second trigger means comprise a resilient expansible slit ring (19) provided with detent teeth, operating in a circular groove (20) formed on said casing (14), provided with slots through which said dement teeth of the ring (19) inwardly protrude inside the bore of said casing.

9. An auto-injector according to claim 4, wherein said tubular protection cover (24) is provided with a flexible radial arm (25) carrying two safety pins (26, 27) intended to be inserted into two corresponding holes (28, 29) formed into said cover (24) in such a position that, when inserted, and with the auto-injector not actuated, the lower pin (27) rest against the edge of the slider (5) while the upper pin (26) rests against an annular shoulder (30) formed on the control sleeve (17), thereby preventing upper movement of the slider and the control sleeve and acting therefore as a safety device.

10. An auto-injector according to claim 5, wherein said elastic sleeve (31) is formed with a longitudinal slit (37), with an upper cylindrical portion (32) provided with an annular projection (33) adapted to slide with friction against the inside wall of cover (24), and with a lower thinner flexible portion which is provided with longitudinal slits.

11. An auto-injector for a medicament prefilled syringe (4, 404), having a head at one end and fitted with a needle (10, 410) at the other end and including a syringe piston (23), said auto-injector incorporating a first device D1 which makes automatic the needle penetration into a user'"'"'s body by releasing of a first trigger means (9, 419) and controls a second device D2 which performs the medicament injection, said first device D1 comprising a slider (5, 405) concentric to said syringe (4, 404), and adapted to be connected to said syringe by means of said first trigger means (9, 419), in a position in which it covers said needle, said first trigger means (9, 419) being releasable when applying a predetermined force on said syringe (4, 404) when said slider (5, 405) is placed against the user'"'"'s body, said second device D2 comprising a piston (21) resting against the syringe piston (23) urged by a compressed spring (22), and second trigger means (19) retaining said piston (21), characterized in that said slider (5, 405) is fitted with an appendix disposed for releasing said second trigger means (19) of said second device D2 when a reciprocal movement of said slider is completed with the result of having the medicament injection beginning only after the complete needle penetration thereby avoiding any medicament delivery at a non-desired depth or site.

12. An auto-injector according to claim 11 wherein at least one of said first and second trigger means comprises a resilient expansible slit ring (9, 419;

19).