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High throughput oligonucleotide synthesizer

  • US 5,681,534 A
  • Filed: 07/20/1995
  • Issued: 10/28/1997
  • Est. Priority Date: 07/20/1995
  • Status: Expired due to Fees
First Claim
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1. A high-throughput oligonucleotide synthesizer for synthesizing multiple oligonucleotides comprising:

  • (a) a pre-existing low-throughput oligonucleotide synthesizer having no more than eight reactor positions;

    (b) a plurality of valve manifolds, each of said valve manifolds having (1) a single inlet port and (2) a plurality of outlet ports;

    (c) a plurality of fluidic connection means, said plurality of fluidic connection means being equal to the number of reactor positions of said pre-existing low-throughput oligonucleotide synthesizer, each of said fluidic connection means having a first end in fluid connection with one of said reactor positions of said pre-existing low-throughput synthesizer and a second end in fluidic connection with one of said inlet ports of said plurality of valve manifolds, such that each of said plurality of valve manifolds is in fluidic connection with one of said reactor positions of said pre-existing low-throughput oligonucleotide synthesizer; and

    (d) a plurality of reactor positions corresponding in number to said plurality of outlet ports of said plurality of valve manifolds, each of said plurality of reactor positions comprising a single reactor inlet and a single reactor outlet and being capable of receiving a reactor column, such that each reactor inlet of said plurality of reactor positions is in fluidic connection with a corresponding valve manifold outlet port;

    whereby the throughput capacity of the pre-existing low-throughput oligonucleotide synthesizer is multiplied by the number of plurality of outlet ports of said plurality of valve manifolds.

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