Methods and compositions for passive immunotherapy

• US 5,681,565 A
• Filed: 01/24/1996
• Issued: 10/28/1997
• Est. Priority Date: 01/12/1993
• Status: Expired due to Fees

• Current Assignee: Medical Sciences Research Institute
• Original Assignee: Medical Sciences Research Institute
• Inventors: Gristina, Anthony G., Giridhar, Girish
• Primary Examiner(s): LORING, SUSAN
• Application Number:
  US08/590,880
• Time in Patent Office: 643 Days
• Field of Search: 424/164.1, 424/130.1, 424/141.1, 424/150.1, 424/163.1, 424/165.1, 424/169.1, 424/170.1, 530/387.1, 530/388.1, 530/388.2, 530/388.4, 530/389.1, 530/389.5
• US Class Current: 424/164.1
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 39/44 Antibodies bound to carriers
• CPC Class Codes: A61L 2300/256 Antibodies, e.g. immunoglobulins, vaccines
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: C07K 16/12 against material from bacteria
• CPC Class Codes: C07K 16/1214 from Pseudomonadaceae (F)
• CPC Class Codes: C07K 16/1271 from Micrococcaceae (F), e.g. Staphylococcus

Abstract

The direct, concentrated local delivery of antibodies, and pooled human immunoglobulins in particular, to tissue surfaces (e.g., wounds, burns, etc.), and biomaterial implant surfaces significantly decreases the rate of infection at those sites and enhances healing. The immunoglobulins serve to opsonize circulating infectants for phagocytosis and killing, prior to microbial adhesion and biofilm formation, and neutralize bacterial toxins. The treatment methodology results in reduced inflammation, reduced complement and tissue damage, and reduced rejection of biomaterials and transplants.

Claims

1. A method for reducing infection associated with implantable and transplantable materials, comprising the steps of:

obtaining a material to be implanted or transplanted into a patient;

coating said material with an antibody composition selected from the group consisting of immunoglobulins, monoclonal antibodies, and mixtures thereof; and

positioning said material in said patient.

2. The method of claim 1 wherein said obtaining step includes the step of selecting an organ or tissue of human or animal origin as said implantable or transplantable material, and wherein said step of positioning is performed by transplanting.

3. The method of claim 2 wherein said coating step is performed by a process selected from the group consisting of dipping and perfusing said organ or tissue.

4. The method of claim 1 wherein said obtaining step includes the step of selecting a biomaterial of non-animal origin as said implantable or transplantable material, and said positioning step is performed by implanting.

5. The method of claim 4 wherein said biomaterial is selected from the group consisting of catheters, total joints, fixation devices, pacemakers, central lines, contact lenses, artificial hearts, pumps, and drug delivery devices.

6. The method of claim 4 wherein said coating step is performed prior to said obtaining and positioning steps.

7. The method of claim 4 wherein said coating step is performed after said obtaining and before said positioning steps.

8. The method of claim 4 further comprising the step of immobilizing antibodies in said antibody composition on at least one surface of said material.

9. A method for enhancing the healing rate of damaged tissue, comprising the steps of:

applying an antibody composition to damaged tissue; and

allowing said damaged tissue to heal, said antibody composition enhancing the rate of healing of said damaged tissue.

10. The method of claim 9 wherein said applying step includes the step of selecting said antibody composition to include immunoglobulins.

11. The method of claim 9 wherein said applying step includes the step of selecting said antibody composition to include monoclonal antibodies.

12. A body contacting device for preventing infection, comprising:

a biomaterial having at least one surface which will be brought into contact with a tissue or organ of a patient; and

an antibody composition positioned on said surface of said biomaterial.

13. The body contacting device of claim 12 further comprising a matrix material positioned on said surface, said antibody composition being positioned within said matrix material on said surface of said biomaterial.

14. The body contacting device of claim 12 wherein said biomaterial is selected from the group consisting of catheters, total joints, fixation devices, pacemakers, central lines, contact lenses, vascular grafts, artificial hearts, pumps, diagnostic and monitoring devices, and devices including polymer packaged cells and therapeutics.