Multilayered controlled-release oral solid pharmaceutical forms
First Claim
Patent Images
1. A solid pharmaceutical composition for oral administration, comprising:
- at least one first layer consisting essentially of a first active material and a disintegrating or superdisintegrating compound which is a cross-linked polyvinylpyrrolidone, sodium carboxy methylcellulose, carboxymethyl starch, potassium methacrylate--divinylbenzene copolymer, a polyvinylalcohol, a starch, a microcrystalline cellulose, a dextrin, beta cyclodextrin, and mixtures thereof; and
at least one second layer located on said first layer containing a portion of said first active material or a second active material and an excipient or adjuvant selected from the group consisting of hydroxypropylmethylcellulose of molecular weight 1,000 to 4,000,000, hydroxypropylcellulose of molecular weight from 2,000 to 2,000,000, a carboxyvinylpolymer, a polyvinylalcohol, a glucan, a scleroglucan, a mannan, a xanthan, alginic acid, methylcellulose and a polymethylcellulose;
said active material in said first layer being released upon administration to a host at a rate faster than the rate of release of said active material in said second layer.
1 Assignment
0 Petitions
Accused Products
Abstract
Multilayered controlled-release solid pharmaceutical composition in tablet form suitable for oral administration comprising at least two layers containing active material in association with excipients and additives. One layer of the tablet releases a portion of the drug quickly while the other layer and optionally further layers release portions of the drug more gradually.
-
Citations
26 Claims
-
1. A solid pharmaceutical composition for oral administration, comprising:
-
at least one first layer consisting essentially of a first active material and a disintegrating or superdisintegrating compound which is a cross-linked polyvinylpyrrolidone, sodium carboxy methylcellulose, carboxymethyl starch, potassium methacrylate--divinylbenzene copolymer, a polyvinylalcohol, a starch, a microcrystalline cellulose, a dextrin, beta cyclodextrin, and mixtures thereof; and at least one second layer located on said first layer containing a portion of said first active material or a second active material and an excipient or adjuvant selected from the group consisting of hydroxypropylmethylcellulose of molecular weight 1,000 to 4,000,000, hydroxypropylcellulose of molecular weight from 2,000 to 2,000,000, a carboxyvinylpolymer, a polyvinylalcohol, a glucan, a scleroglucan, a mannan, a xanthan, alginic acid, methylcellulose and a polymethylcellulose; said active material in said first layer being released upon administration to a host at a rate faster than the rate of release of said active material in said second layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
-
Specification