Method and composition for removal of excess hydrogen ions from humans

• US 5,683,356 A
• Filed: 07/01/1996
• Issued: 11/04/1997
• Est. Priority Date: 02/17/1994
• Status: Expired due to Fees

• Current Assignee: Rossmark Medical Publishers Incorporated
• Original Assignee: Rossmark Medical Publishers Incorporated
• Inventors: Cheema-Dhadli, Surinder, Halperin, Mitchell Lewis
• Primary Examiner(s): Prebilic, Paul B.
• Application Number:
  US08/673,137
• Time in Patent Office: 491 Days
• Field of Search: 604/4, 604/5, 128/898
• US Class Current: 604/5.01
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof

Abstract

A compound or composition incorporating silver carbonate is for use in removing excess hydrogen ions in a patient. The silver carbonate reacts with chloride ions which naturally occur in the patient'"'"'s body fluids to produce a silver chloride precipitate. The chemical reaction producing silver chloride causes the release of hydroxyl, carbonate and/or bicarbonate ions which react with free hydrogen ions to form carbon dioxide and water. The silver carbonate compound or composition may be provided in a blood filtration cartridge, syringe or an orally ingestible form either alone or surrounded by a selectively permeable membrane. The membrane is selected to permit movement of ions, as well as carbon dioxide and water molecules therethrough, while preventing the silver carbonate or silver chloride precipitate from being released into the patient.

Claims

1. A method of removing excess hydrogen ions in a patient'"'"'s body fluid comprising,

contacting said body fluid with a therapeutically effective amount of a hydrogen ion buffering means for bonding with free anions naturally present in said fluid and substituting therefore buffering ions which bond with said hydrogen ions to produce water and carbon dioxide molecules,

wherein said therapeutically effective amount is an amount selected so as to lessen the likelihood of adverse health effects of excess hydrogen ions in said patient'"'"'s body, and said buffering means comprising Ag₂ CO₃.

5. The method of claim 1 wherein said body fluid is contacted with said buffering means in vivo.

6. The method of claim 1 wherein said body fluid is contacted with said buffering means in vitro.

7. The method of claim 1 wherein said buffering means further comprises a carrier selected from the group consisting of an anion exchanger on dextran, an anion exchanger on agarose, an anion exchanger on cellulose and an anion exchanger on polystyrene.

8. The method of claim 1 wherein said free anions comprise chloride ions.

9. The method of claim 7 wherein said free anions comprise chloride ions.

10. The method of claim 9 wherein said composition further includes an anion exchange resin for bonding with sulphate or phosphate anions naturally present in said fluid and substituting therefore carbonate ions or bicarbonate ions.

11. The method of claim 1 wherein said buffering means is administered to said patient in conjunction with a composition for binding free potassium ions.

12. The method of claim 1 wherein said buffering means is encapsulated within a selectively permeable membrane which permits ion flow between said patient'"'"'s body fluid and said buffering means while preventing movement of said buffering means into said patient.

13. The method of claim 12 wherein said selectively permeable membrane is a natural cellulose membrane.

19. The method as claimed in claim 1 where said step of contacting said body fluid is performed to buffer increased hydrogen ion concentrations resulting from a medical condition selected from the group consisting of a heart attack, poor renal function and acute renal failure.

2. A method of removing excess hydrogen ions in a patient'"'"'s body fluid comprising,

contacting said body fluid with hydrogen ion buffering means for bonding with free anions naturally present in said fluid and substituting therefore buffering ions which bond with said hydrogen ions to produce water and carbon dioxide molecules,

wherein said step of contacting said body fluid further comprises orally ingesting said buffering means, and

said buffering means comprising Ag₂ CO₃.

14. The method of claim 2 wherein said buffering means is administered to said patient in conjunction with a composition for binding free potassium ions.

15. The method of claim 2 wherein said buffering means further comprises a carrier selected from the group consisting of an anion exchanger on dextran, an anion exchanger on agarose, an anion exchanger on cellulose and an anion exchanger on polystyrene.

17. The method of claim 2 wherein said buffering means is encapsulated within a selectively permeable membrane which permits ion flow between said patient'"'"'s body fluid and said buffering means while preventing movement of said buffering means into said patient.

3. A method of removing excess hydrogen ions in a patient'"'"'s body fluid comprising the steps of:

extracting said body fluid from said patient,

contacting said body fluid with a hydrogen ion buffering means for bonding with free anions naturally present in said fluid and substituting therefore buffering ions with bond with said hydrogen ions to produce water and carbon dioxide molecules, and

reintroducing said body fluid into said patient,

wherein said buffering means comprising Ag₂ CO₃.

16. The method of claim 3 wherein said buffering means further comprises a carrier selected from the group consisting of an anion exchanger on dextran, an anion exchanger on agarose, an anion exchanger on cellulose and an anion exchanger on polystyrene.

18. The method of claim 3 wherein said buffering means is encapsulated within a selectively permeable membrane which permits ion flow between said patient'"'"'s body fluid and said buffering means while preventing movement of said buffering means into said patient.

20. The method as claimed in claim 3 wherein prior to said step of reintroducing said fluid into said patient, said fluid is passed through a selectively permeable membrane which prevents movement of said buffering means therethrough.

4. A method of reducing the likelihood of adverse health effects of excess hydrogen ions in an individual resulting from a medical condition selected from the group consisting of a heart attack, poor renal function and acute renal failure, said method including the step of,

contacting a body fluid of said individual with a therapeutically effective amount of buffering means comprising Ag₂ CO₃, said buffering means for bonding with free chloride ions naturally present in said body fluid and substituting therefore buffering ions selected from the group consisting of carbonate ions and bicarbonate ions, and wherein said buffering ions bond with said hydrogen ions to produce water and carbon dioxide molecules.